Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/14508
Registro completo de metadados
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Naveca, Felipe Gomes | - |
dc.contributor.author | Pontes, Gemilson Soares | - |
dc.contributor.author | Chang, Aileen Yu Hen | - |
dc.contributor.author | Silva, George Allan Villarouco da | - |
dc.contributor.author | Nascimento, Valdinete Alves do | - |
dc.contributor.author | Monteiro, Dana Cristina da Silva | - |
dc.contributor.author | Silva, Marineide Souza da | - |
dc.contributor.author | Abdalla, Lígia Fernandes | - |
dc.contributor.author | Santos, João Hugo Abdalla | - |
dc.contributor.author | Almeida, Tatiana Amaral Pires de | - |
dc.contributor.author | Mejía, Matilde Del Carmen Contreras | - |
dc.contributor.author | Mesquita, Tirza Gabrielle Ramos de | - |
dc.contributor.author | Encarnação, Helia Valeria de Souza | - |
dc.contributor.author | Gomes, Matheus Souza | - |
dc.contributor.author | Amaral, L. Rodrigues | - |
dc.contributor.author | Campi-Azevedo, Ana Carolina | - |
dc.contributor.author | Coelho-Dos-Reis, Jordana Grazziela Alves | - |
dc.contributor.author | Antonelli, Lis R. | - |
dc.contributor.author | Teixeira-Carvalho, Andréa | - |
dc.contributor.author | Martins-Filho, Olindo Assis | - |
dc.contributor.author | Ramasawmy, Rajendranath | - |
dc.date.accessioned | 2020-04-24T16:49:21Z | - |
dc.date.available | 2020-04-24T16:49:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/14508 | - |
dc.description.abstract | BACKGROUND Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis. OBJECTIVES To define the immunologic biomarkers that correlate with acute ZIKV infection. METHODS We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining. FINDINGS ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection. Interestingly, the inflammatory cytokines IL-1β, IL-13, IL-17, TNF-α, and IFN-γ; chemokines CXCL8, CCL2, CCL5; and the growth factor G-CSF, displayed a bimodal distribution accompanying viremia. While this is the first manuscript to document bimodal distributions of viremia in ZIKV infection, this has been documented in other viral infections, with a primary viremia peak during mild systemic disease and a secondary peak associated with distribution of the virus to organs and tissues. MAIN CONCLUSIONS Biomarker network analysis demonstrated distinct dynamics in concurrence with the bimodal viremia profiles at different time points during ZIKV infection. Such a robust cytokine and chemokine response has been associated with blood-brain barrier permeability and neuroinvasiveness in other flaviviral infections. High-dimensional data analysis further identified CXCL10, a chemokine involved in foetal neuron apoptosis and Guillain-Barré syndrome, as the most promising biomarker of acute ZIKV infection for potential clinical application. © 2018, Fundacao Oswaldo Cruz. All rights reserved. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 113, Número 6 | pt_BR |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Brazil | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/br/ | * |
dc.subject | Biological Marker | en |
dc.subject | Chemokine | en |
dc.subject | Cytokine | en |
dc.subject | Gamma Interferon Inducible Protein 10 | en |
dc.subject | Acute Disease | en |
dc.subject | Adult | en |
dc.subject | Blood | en |
dc.subject | Case Control Study | en |
dc.subject | Complication | en |
dc.subject | Cross-sectional Study | en |
dc.subject | Female | en |
dc.subject | Gene Expression | en |
dc.subject | Human | en |
dc.subject | Immunology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Zika Fever | en |
dc.subject | Acute Disease | en |
dc.subject | Adult | en |
dc.subject | Biomarkers | en |
dc.subject | Case-control Studies | en |
dc.subject | Chemokine Cxcl10 | en |
dc.subject | Chemokines | en |
dc.subject | Cross-sectional Studies | en |
dc.subject | Cytokines | en |
dc.subject | Female | en |
dc.subject | Gene Expression | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Zika Virus Infection | en |
dc.title | Analysis of the immunological biomarker profile during acute zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1590/0074-02760170542 | - |
dc.publisher.journal | Memórias do Instituto Oswaldo Cruz | pt_BR |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
artigo-inpa.pdf | 6,21 MB | Adobe PDF | Visualizar/Abrir |
Este item está licenciada sob uma Licença Creative Commons