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Título: | Amazonian plant natural products: Perspectives for discovery of new antimalarial drug leads |
Autor: | Pohlit, Adrian Martin Lima, Renata Braga Souza Frausin, Gina Silva, Luiz Francisco Rocha e Lopes, Stefanie C. P. Moraes, Carolina Borsoi Cravo, Pedro Vítor Lemos Lacerda, Marcus V. G. Siqueira, Andre M. Freitas, Lucio H. Costa, Fábio Trindade Maranhão |
Palavras-chave: | Antimalarial Agent Biological Product Chloroquine Quinine Antimalarial Agent Artemisia Annua Chemistry Drug Development Drug Effect Human Malaria Parasitology Pathogenicity Pathology Plasmodium Falciparum Review Drug Effects Malaria Plasmodium Falciparum Antimalarials Artemisia Annua Biological Products Chloroquine Drug Discovery Humans Malaria Plasmodium Falciparum Quinine Antimalarials Artemisia Annua Biological Products Chloroquine Drug Discovery Humans Malaria Plasmodium Falciparum Quinine |
Data do documento: | 2013 |
Revista: | Molecules |
É parte de: | Volume 18, Número 8, Pags. 9219-9240 |
Abstract: | Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed. New antimalarials that block transmission of Plasmodium spp. from humans to Anopheles mosquito vectors are key to malaria eradication efforts. Although P. vivax causes a considerable number of malaria cases, its importance has for long been neglected. Vivax malaria can cause severe manifestations and death; hence there is a need for P. vivax-directed research. Plants used in traditional medicine, namely Artemisia annua and Cinchona spp. are the sources of the antimalarial natural products artemisinin and quinine, respectively. Based on these compounds, semi-synthetic artemisinin-derivatives and synthetic quinoline antimalarials have been developed and are the most important drugs in the current therapeutic arsenal for combating malaria. In the Amazon region, where P. vivax predominates, there is a local tradition of using plant-derived preparations to treat malaria. Here, we review the current P. falciparum and P. vivax drug-sensitivity assays, focusing on challenges and perspectives of drug discovery for P. vivax, including tests against hypnozoites. We also present the latest findings of our group and others on the antiplasmodial and antimalarial chemical components from Amazonian plants that may be potential drug leads against malaria. © 2013 by the authors; licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/molecules18089219 |
Aparece nas coleções: | Artigos |
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