Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/17759
Registro completo de metadados
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Tarragô, Andréa Monteiro | - |
dc.contributor.author | Costa, Allyson Guimarães da | - |
dc.contributor.author | Pimentel, João Paulo Diniz | - |
dc.contributor.author | Gomes, Samara Tatielle Monteiro | - |
dc.contributor.author | Freitas, Felipe Bonfim | - |
dc.contributor.author | Lalwani, Pritesh | - |
dc.contributor.author | Araújo, Ana Ruth Silva de | - |
dc.contributor.author | Silva Victória, Flamir da | - |
dc.contributor.author | Victória, Marilú Barbieri | - |
dc.contributor.author | Vallinoto, Antônio Carlos Rosário | - |
dc.contributor.author | Sadahiro, Aya | - |
dc.contributor.author | Teixeira-Carvalho, Andréa | - |
dc.contributor.author | Martins-Filho, Olindo Assis | - |
dc.contributor.author | Malheiro, Adriana | - |
dc.date.accessioned | 2020-06-15T21:49:08Z | - |
dc.date.available | 2020-06-15T21:49:08Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/17759 | - |
dc.description.abstract | We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 47 healthy controls. The HCV patients had higher IL-6, IL-2, IFN-γ, IL-10, and IL-17A levels than the controls. HCV G1 patients had higher IL-2 and IFN-γ levels than G2 patients. The -174IL6G>. C, -308TNFαG>. A, and -1082IL10A>. G variants were similarly distributed in both groups. However, HCV patients with the -174IL6GC variant had higher IL-2 and IFN-γ levels than patients with the GG and CC variants. Additionally, HCV patients with the -308TNFαGG genotype had higher IL-17A levels than patients with the AG genotype, whereas patients with the -1082IL10GG variant had higher IL-6 levels than patients with the AA and AG variants. A significant proportion of HCV patients had high levels of both IL-2 and IFN-γ. The subgroup of HCV patients with the G1/IL6CG/TNFαGG association displayed the highest proportions of high producers of IL-2 and IFN-γ whereas the subgroup with the G1/TNFαGG profile showed high proportions of high producers of IL-6 and IL-17A. HCV patients with other HCV/cytokine genotype associations showed no particular cytokine profile. Our results suggest that HCV genotype G1 and IL-6 and TNF-α polymorphisms have a clinically relevant influence on serum pro-inflammatory cytokine profile (IL-2 and IFN-γ) in HCV patients. © 2014 American Society for Histocompatibility and Immunogenetics. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 75, Número 11, Pags. 1075-1083 | pt_BR |
dc.rights | Restrito | * |
dc.subject | Cytokine | en |
dc.subject | Gamma Interferon | en |
dc.subject | Interleukin-10 | en |
dc.subject | Interleukin-17 | en |
dc.subject | Interleukin-2 | en |
dc.subject | Interleukin-4 | en |
dc.subject | Interleukin-6 | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.subject | Gamma Interferon | en |
dc.subject | Il10 Protein, Human | en |
dc.subject | Il17a Protein, Human | en |
dc.subject | Il4 Protein, Human | en |
dc.subject | Il6 Protein, Human | en |
dc.subject | Interleukin-10 | en |
dc.subject | Interleukin-17 | en |
dc.subject | Interleukin-2 | en |
dc.subject | Interleukin-4 | en |
dc.subject | Interleukin-6 | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.subject | Blood Donor | en |
dc.subject | Brazilian | en |
dc.subject | Controlled Study | en |
dc.subject | Disease Course | en |
dc.subject | Dna Polymorphism | en |
dc.subject | Female | en |
dc.subject | Flow Cytometry | en |
dc.subject | Genetic Association | en |
dc.subject | Genotype | en |
dc.subject | Hepatitis C | en |
dc.subject | Hepatitis C Virus Genotype 1 | en |
dc.subject | Human | en |
dc.subject | Immunogenetics | en |
dc.subject | Major Clinical Study | en |
dc.subject | Male | en |
dc.subject | Polymorphism, Restriction Fragment Length | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Adult | en |
dc.subject | Blood | en |
dc.subject | Case Control Study | en |
dc.subject | Hepatitis C, Chronic | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Genetics | en |
dc.subject | Growth, Development And Aging | en |
dc.subject | Hepacivirus | en |
dc.subject | Host-pathogen Interaction | en |
dc.subject | Virology | en |
dc.subject | Adult | en |
dc.subject | Case-control Studies | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Hepacivirus | en |
dc.subject | Hepatitis C, Chronic | en |
dc.subject | Host-pathogen Interactions | en |
dc.subject | Humans | en |
dc.subject | Interferon-gamma | en |
dc.subject | Interleukin-10 | en |
dc.subject | Interleukin-17 | en |
dc.subject | Interleukin-2 | en |
dc.subject | Interleukin-4 | en |
dc.subject | Interleukin-6 | en |
dc.subject | Male | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Tumor Necrosis Factor-alpha | en |
dc.title | Combined impact of hepatitis C virus genotype 1 and interleukin-6 and tumor necrosis factor-α polymorphisms on serum levels of pro-inflammatory cytokines in Brazilian HCV-infected patients | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1016/j.humimm.2014.08.198 | - |
dc.publisher.journal | Human Immunology | pt_BR |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.