Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/18545
Registro completo de metadados
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Abreu, Heitor Avelino de | - |
dc.contributor.author | Aparecida Dos, Izandina | - |
dc.contributor.author | Souza, Gilmar P. | - |
dc.contributor.author | Piló?-Veloso, Dorila | - |
dc.contributor.author | Duarte, Hélio Anderson | - |
dc.contributor.author | Alcântara, Antônio Flávio de C. | - |
dc.date.accessioned | 2020-06-15T22:02:05Z | - |
dc.date.available | 2020-06-15T22:02:05Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/18545 | - |
dc.description.abstract | (+)-Bergenin (1) was isolated from Sacoglottis uchi, a species of vegetable found in the Amazon region and popularly used for the treatment of several hepatic problems. The structure of 1 was fully characterized using IR, GC-MS and NMR (1D and 2D) analyses. This phytoconstituent has been used as an oriental folk medicine for the treatment of many diseases and shows antihepatotoxic properties. Tests with β-carotene, DPPH and a heterogeneous Fenton system were carried out, confirming the antioxidant activity of 1. Theoretical calculations were performed to investigate the formation of the radical derivatives of 1 using ̇H, ̇OH, ̇CH3, and ̇CCl 3 as initiator radicals. DFT thermodynamic calculations showed that the methoxyl group (O-6-CH3) is the most favorable site for radical attack. Frontier molecular orbital analysis showed that nucleophilic radical attack is favored on the aromatic ring of 1 where the LUMO is localized, with antibonding character with respect to the O-6-CH3 bond. The possibilities of attack at other sites on 1 were investigated in detail in order to understand the regiospecificity of this reaction. © The Royal Society of Chemistry. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 6, Número 15, Pags. 2713-2718 | pt_BR |
dc.rights | Restrito | * |
dc.subject | Nuclear Magnetic Resonance | en |
dc.subject | Amazon Region | en |
dc.subject | Anti-oxidant Activities | en |
dc.subject | Bergenin | en |
dc.subject | Fenton System | en |
dc.subject | Theoretical Calculations | en |
dc.subject | Health | en |
dc.subject | Antioxidant | en |
dc.subject | Benzopyran Derivative | en |
dc.subject | Bergenin | en |
dc.subject | Beta Carotene | en |
dc.subject | Biphenyl Derivative | en |
dc.subject | Diphenyl-p-picrylhydrazyl | en |
dc.subject | Diphenyl-p-picrylhydrazyl | en |
dc.subject | Hydrazine Derivative | en |
dc.subject | Hydroxyl Radical | en |
dc.subject | Plant Extract | en |
dc.subject | Bark | en |
dc.subject | Chemical Structure | en |
dc.subject | Chemistry | en |
dc.subject | Computer Simulation | en |
dc.subject | Spectrophotometry, Infrared | en |
dc.subject | Malpighiaceae | en |
dc.subject | Mass Fragmentography | en |
dc.subject | Medicinal Plant | en |
dc.subject | Nuclear Magnetic Resonance Spectroscopy | en |
dc.subject | South America | en |
dc.subject | Stereoisomerism | en |
dc.subject | Antioxidants | en |
dc.subject | Benzopyrans | en |
dc.subject | Beta Carotene | en |
dc.subject | Biphenyl Compounds | en |
dc.subject | Computer Simulation | en |
dc.subject | Gas Chromatography-mass Spectrometry | en |
dc.subject | Hydrazines | en |
dc.subject | Hydroxyl Radical | en |
dc.subject | Magnetic Resonance Spectroscopy | en |
dc.subject | Malpighiaceae | en |
dc.subject | Molecular Structure | en |
dc.subject | Plant Bark | en |
dc.subject | Plant Extracts | en |
dc.subject | Plants, Medicinal | en |
dc.subject | South America | en |
dc.subject | Spectrophotometry, Infrared | en |
dc.subject | Stereoisomerism | en |
dc.subject | Sacoglottis | en |
dc.title | Antioxidant activity of (+)-bergenin-a phytoconstituent isolated from the bark of Sacoglottis uchi Huber (Humireaceae) | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1039/b804385j | - |
dc.publisher.journal | Organic and Biomolecular Chemistry | pt_BR |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.