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dc.contributor.authorFerraroni, JoséJ J.-
dc.contributor.authorSpeer, Clarence A.-
dc.contributor.authorHayes, J.-
dc.contributor.authorSuzuki, Mamoru-
dc.date.accessioned2020-06-15T22:12:09Z-
dc.date.available2020-06-15T22:12:09Z-
dc.date.issued1981-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/19727-
dc.description.abstractThe prevalence of chloroquine-resistant falciparum malaria was determined for humans living at 28 different sites in the Brazilian Amazon. Blood samples obtained from each patient were defibrinated, placed in vials containing 0.5% glucose and or chloroquine and incubated for 24 hours at 39-40°C without agitation. In vitro sensitivity of the parasite to four different concentrations of chloroquine was determined for each sample. After 24 hours of incubation, trophozoites of Plasmodium falciparum developed to schizonts in all control cultures (no chloroquine) as well as in 80.6, 48.4, 11.8 and 7.5% of the cultures containing 0.5, 1.0, 2.0, and 3.0 nmol chloroquine/ml blood, respectively. Chloroquine-resistant P. falciparum was found in blood samples from all 28 locations, indicating that such resistance is widely spread in the Brazilian Amazon.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 30, Número 3, Pags. 526-530pt_BR
dc.rightsRestrito*
dc.subjectChloroquineen
dc.subjectAnimals Experimenten
dc.subjectDrug Resistanceen
dc.subjectDrug Responseen
dc.subjectEpidemiologyen
dc.subjectGeographic Distributionen
dc.subjectIn Vitro Studyen
dc.subjectMalariaen
dc.subjectPlasmodium Falciparumen
dc.subjectProtozoonen
dc.subjectAnimalsiaen
dc.subjectPlasmodium Falciparumen
dc.subjectProtozoaen
dc.titlePrevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazonen
dc.typeArtigopt_BR
dc.identifier.doi10.4269/ajtmh.1981.30.526-
dc.publisher.journalAmerican Journal of Tropical Medicine and Hygienept_BR
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