Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/14525
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dc.contributor.authorAndrade Neto, Valter Ferreira de-
dc.contributor.authorPohlit, Adrian Martin-
dc.contributor.authorPinto, Ana Cristina da Silva-
dc.contributor.authorSilva, Ellen Cristina Costa-
dc.contributor.authorNogueira, Karla Lagos-
dc.contributor.authorMelo, Márcia R.S.-
dc.contributor.authorHenrique, Marycleuma Campos-
dc.contributor.authorAmorim, Rodrigo C.N.-
dc.contributor.authorSilva, Luis Francisco Rocha-
dc.contributor.authorCosta, Mônica Regina Farias-
dc.contributor.authorNunomura, Rita de Cássia Saraiva-
dc.contributor.authorNunomura, Sergio Massayoshi-
dc.contributor.authorAlecrim, Wilson Duarte-
dc.contributor.authorAlecrim, Maria das Graças Costa-
dc.contributor.authorChaves, Francisco Célio Maia-
dc.contributor.authorVieira, Pedro Paulo Ribeiro-
dc.date.accessioned2020-04-24T16:49:27Z-
dc.date.available2020-04-24T16:49:27Z-
dc.date.issued2007-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/14525-
dc.description.abstractIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 102, Número 3, Pags. 359-365pt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectAntimalarial Agenten
dc.subjectPlant Extracten
dc.subjectAnimalsen
dc.subjectApocynaceaeen
dc.subjectBrasilen
dc.subjectChemistryen
dc.subjectDrug Effecten
dc.subjectDrug Sensitivityen
dc.subjectIsolation And Purificationen
dc.subjectPlasmodium Falciparumen
dc.subjectSimaroubaceaeen
dc.subjectAnimalen
dc.subjectAntimalarialsen
dc.subjectApocynaceaeen
dc.subjectBrasilen
dc.subjectParasitic Sensitivity Testsen
dc.subjectPlant Extractsen
dc.subjectPlasmodium Falciparumen
dc.subjectSimaroubaceaeen
dc.subjectApocynaceaeen
dc.subjectAspidospermaen
dc.subjectAspidosperma Desmanthumen
dc.subjectLepianthes Peltataen
dc.subjectPicrolemmaen
dc.subjectPiperaceaeen
dc.subjectPlasmodium Falciparumen
dc.subjectSimaroubaceaeen
dc.titleIn vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plantsen
dc.typeArtigopt_BR
dc.identifier.doi10.1590/S0074-02762007000300016-
dc.publisher.journalMemórias do Instituto Oswaldo Cruzpt_BR
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