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Title: Insertion sequences as variability generators in the Mycoplasma hyopneumoniae and M. synoviae genomes
Authors: Loreto, Elgion Lúcio da Silva
Ortiz, Mauro Freitas
Porto, Jorge Ivan Rebelo
Keywords: Genome, Bacterial
Bacterial Strain
Controlled Study
Gene Insertion
Gene Rearrangement
Gene Sequence
Gene Transfer
Genetic Variability
Mycoplasma Gallisepticum
Mycoplasma Hyopneumoniae
Mycoplasma Synoviae
Nucleotide Sequence
Open Reading Frame
Mycoplasma Gallisepticum
Mycoplasma Hyopneumoniae
Mycoplasma Synoviae
Issue Date: 2007
metadata.dc.publisher.journal: Genetics and Molecular Biology
metadata.dc.relation.ispartof: Volume 30, Número SUPPL. 1, Pags. 283-289
Abstract: We have analyzed the sequenced genomes of three strains of Mycoplasma hyopneumoniae and one strain of M. synoviae, and have found three and two different transposable element families, respectively in each species. In M. hyopneumoniae, the Insertion Sequences of the IS4 family is represented by ISMHp1, a putatively active element. The IS3 family is represented by several degenerated sequences. A third element called tMH was found, which shows some characteristics reminiscent of retrotransposons. In M. synoviae, three different possibly active IS4 elements are present (ISMHp1-like; ISMs1 and IS1634-like elements). The 1S30 family is represented by the degenerated IS1630-like element. The IS1634-like element is shown to be involved in chromosomal rearrangements and horizontal gene transfer (HGT). The ISMHp1-like element is shown to relate to the HGT of a 25-kb region from M. gallisepticum to M. synoviae. The fractions of these genomes that correspond to mobile elements varied from 1.35 to 3.13% in M. hyopneumonia strains and was 2.08% in M. synoviae. Although these species possess reduced genomes, they maintain mobile elements, perhaps as a mechanism for genetic variability production. Copyright by the Brazilian Society of Genetics.
metadata.dc.identifier.doi: 10.1590/S1415-47572007000200017
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