Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/16049
Título: The Genome of Anopheles darlingi, the main neotropical malaria vector
Autor: Marinotti, Osvaldo
Cerqueira, Gustavo C.
Almeida, Luiz G.P.
Ferro, Maria Inês Tiraboschi
Loreto, Elgion Lúcio da Silva
Zaha, Arnaldo
Teixeira, Santuza Ribeiro
Wespiser, Adam R.
e Silva, A. A.
Schlindwein, Aline Daiane
Pacheco, Ana Carolina Landim
Silva, Artur
Graveley, Brenton R.
Walenz, Brian P.
Araújo Lima, Bruna de
Ribeiro, Carlos Alexandre Gomes
Nunes-Silva, Carlos Gustavo
Carvalho, Carlos Roberto de
Almeida Soares, Célia Maria A. de
Menezes, Cláudia Beatriz Afonso de
Matiolli, Cleverson Carlos
Caffrey, Daniel R.
Araujo, Demetrius Antonio Machado
Oliveira, Diana Magalhães de
Golenbock, Douglas T.
Grisard, Edmundo Carlos
Fantinatti-Garboggini, Fabiana
Carvalho, Fabíola Marques de
Barcellos, Fernando Gomes
Prosdocimi, Francisco
May, Gemma
Azevedo Júnior, Gilson Martins de
Guimarães, Giselle Moura
Goldman, Gustavo Henrique
Padilha, Itácio Q.M.
Batista, Jacqueline da Silva
Ferro, Jesus Aparecido
Ribeiro, J. M.C.
Serrao, Jose Eduardo Lopes Rangel
Dabbas, Karina Maia
Cerdeira, Louise Teixeira
Agnez-Lima, Lucymara Fassarella
Brocchi, Marcelo
Carvalho, Marcos Oliveira de
Teixeira, Marcus de Melo
Mascena Diniz Maia, Maria de
Goldman, Maria Helena S.
Schneider, Maria Paula Cruz
Felipe, Maria Sueli Soares
Hungría, Mariangela
Nicolás, Marisa Fabiana
Pereira, Maristela
Montes, Martín Alejandro
Cantão, Maurício Egídio
Vincentz, Michel G.A.
Rafael, Míriam Silva
Silverman, Neal
Stoco, Patrícia Hermes
Souza, Rangel Celso
Vicentini, Renato
Gazzinelli, Ricardo Tostes Ostes
Oliveira Neves, Rogério de
Silva, Rosane A.
Astolfi-Filho, Spártaco A.T.
Maciel, Talles Eduardo Ferreira
Ürményi, Turán Péter
Tadei, Wanderli Pedro
Camargo, Erney Plessmann
Vasconcelos, Ana Tereza
Palavras-chave: Anopheles
Anopheles Darlingi
Anopheles Gambiae
Circadian Rhythm
Female
Gene Identification
Gene Sequence
Genetic Conservation
Genetic Marker
Genome Analysis
Genome Size
Indel Mutation
Insect Genetics
Insecticide Resistance
Male
Nonhuman
Priority Journal
Sequence Homology
Polymorphism, Single Nucleotide
Synteny
Transposon
Xenobiotic Metabolism
Animal
Anopheles
Chromosomes, Insect
Dna Transposable Elements
Evolution, Molecular
Female
Genetic Variation
Genome, Insect
Host-parasite Interactions
Insect Proteins
Insect Vectors
Insecticide Resistance
Insecticides
Malaria
Male
Molecular Sequence Annotation
Phylogeny
Synteny
Transcriptome
Data do documento: 2013
Revista: Nucleic Acids Research
Encontra-se em: Volume 41, Número 15, Pags. 7387-7400
Abstract: Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles- darlingi. © 2013 The Author(s).
DOI: 10.1093/nar/gkt484
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