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Título: The influence of a TNF gene polymorphism on the severity of rheumatoid arthritis in the Brazilian Amazon
Autor: Boechat, Antonio Luiz
Boechat, Narjara de Oliveira
Ogusku, Maurício Morishi
Alencar, Mariana Raposo
Abensur, Themis da Costa
Neto, José Cardoso
Amorim, Leilian de Souza
Oliveira, Lívia Moura de
Sadahiro, Aya
Santos, Maria Cristina dos
Palavras-chave: Disease Modifying Antirheumatic Drug
Rheumatoid Factor
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Alpha Inhibitor
Clinical Feature
Confidence Interval
Controlled Study
Disease Duration
Disease Severity
Dna Extraction
Gene Frequency
Polymorphism, Genetic
Genetic Susceptibility
Health Assessment Questionnaire
Logistic Regression Analysis
Major Clinical Study
Polymerase Chain Reaction
Priority Journal
Promoter Region
Polymorphism, Restriction Fragment Length
Arthritis, Rheumatoid
Risk Assessment
Tnf Gene
Arthritis, Rheumatoid
Case-control Studies
Genetic Predisposition To Disease
Logistic Models
Middle Aged
Models, Genetic
Polymorphism, Single Nucleotide
Reproducibility Of Results
Roc Curve
Tumor Necrosis Factor-alpha
Young Adult
Data do documento: 2013
Revista: Cytokine
É parte de: Volume 61, Número 2, Pags. 406-412
Abstract: Purpose: The aim of this study was to investigate the influence of the TNF -308 G/A polymorphism in the promoter region of the tumor necrosis factor- α gene on the susceptibility and severity of rheumatoid arthritis (RA) in individuals from the Brazilian Amazon. Methods: A total of 323 individuals-192 healthy controls without arthritis and 131 individuals suffering from arthritis-were genotyped for this polymorphism using a methodology based on PCR-RFLP. Results: The frequency of the A allele (TNF2) in rheumatoid arthritis sufferers was not significantly higher than in the controls (p= 0.926; OR = 0.97; confidence interval 0.54-1.76). However, using a logistic regression model, when the patients were stratified according to whether the manifestations were preponderantly articular or systemic, there was a strong association between the TNF2 allele and systemic arthritis (p= 0.001; OR = 5.89; confidence interval = 1.98-17.5) as well as the use of anti-TNF immunotherapy (p= 0.023; OR = 1.10; confidence interval = 1.00-1.14). The main factors that were found to influence the risk of extra-articular disease were age greater than or equal to 60. years (p= 0.008; OR = 4.06; confidence interval = 1.45-11.38), disease duration greater than 10. years (p= 0.031; OR = 3.10; confidence interval = 1.11-8.63) and positive rheumatoid factor (p= 0.035; OR = 2.07; confidence interval = 1.05-4.09). Conclusions: These results suggest that the TNF2 allele is associated with the more serious forms of the disease in individuals from the Brazilian Amazon but not with a risk for developing RA. © 2012 Elsevier Ltd.
DOI: 10.1016/j.cyto.2012.11.020
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