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|Título:||COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence|
|Autor:||Naveca, Felipe Gomes|
Nascimento, Valdinete Alves Do
Souza, Victor Costa de
Corado, André Lima Guerra
Nascimento, Fernanda Oliveira Do
Silva, George Allan Villarouco Da
Duarte, Débora Camila Gomes
Pessoa, Karina Pinheiro
Mejía, Matilde Del Carmen Contreras
Brandão, Maria Júlia
Jesus, Michele S.
Gonçalves, Luciana Mara Fé
da Costa, Cristiano Fernandes
S. Sampaio, Vanderson
Pontes, Gemilson Soares
Abdalla, Lígia Fernandes
Santos, João Hugo Abdalla
Arantes, Ighor L.G.
Dezordi, Filipe Zimmer
Siqueira, Marilda Mendonça Teixeira De
Wallau, G. L.
Resende, Paola Cristina
Delatorre, Edson Oliveira
|Data do documento:||2021|
|Abstract:||The northern state of Amazonas is among the regions in Brazil most heavily affected by the COVID-19 epidemic and has experienced two exponentially growing waves, in early and late 2020. Through a genomic epidemiology study based on 250 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from different Amazonas municipalities sampled between March 2020 and January 2021, we reveal that the first exponential growth phase was driven mostly by the dissemination of lineage B.1.195, which was gradually replaced by lineage B.1.1.28 between May and June 2020. The second wave coincides with the emergence of the variant of concern (VOC) P.1, which evolved from a local B.1.1.28 clade in late November 2020 and replaced the parental lineage in <2 months. Our findings support the conclusion that successive lineage replacements in Amazonas were driven by a complex combination of variable levels of social distancing measures and the emergence of a more transmissible VOC P.1 virus. These data provide insights to understanding the mechanisms underlying the COVID-19 epidemic waves and the risk of dissemination of SARS-CoV-2 VOC P.1 in Brazil and, potentially, worldwide. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.|
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