Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/37996
Título: | Epidemiological and liver biomarkers profile of epstein-barr virus infection and its coinfection with cytomegalovirus in patients with hematological diseases |
Autor: | Ferrari de Freitas, Lilian de Melo Silva, Jean Nogueira Barbosa, Anderson Miranda Santos, Enzo Pinheiro-Silva, Renato Soares Pontes, Gemilson |
Palavras-chave: | Coinfection Cytomegalovirus Epstein-Barr Ferritin Hematological diseases Prevalence |
Data do documento: | 2021 |
Revista: | Biomolecules |
É parte de: | Volume 11, Número 11 |
Abstract: | Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are viruses globally distributed that have been associated with the development and prognosis of many pathologies, including hematological diseases. This study aimed to characterize the epidemiological profile of EBV infection and the infection-correlated hepatic manifestations in patients with hematological diseases of the northern Brazilian state of Amazonas. A total of 228 patients were serologically tested for the presence of anti-EBV and anti-CMV IgG antibodies through an enzyme-linked immunosorbent assay. The coinfection with CMV, sociodemographic and laboratory records of all patients were also assessed. The overall prevalence observed among the study population for EBV infection and EBV/CMV coinfection was 85.09% (95% CI: 0.80–0.90) and 78.51% (95% CI: 0.73–0.84), respectively. The age group 31–40 years old were more susceptible to EBV/CMV coinfection (95% CI: 1.59–93.41, p = 0.011), while young people aged 1–10 years old were less affected for both EBV infection (CI 95%; 0.66–0.91, p = 0.001) and EBV/CMV coinfection (95% CI: 0.52–0.81, p < 0.0001). High serum levels of the liver biomarker ferritin were associated with EBV infection (95% CI: 1.03–1.54, p = 0.031) and EBV/CMV coinfection (95% CI: 1.02–1.70, p = 0.038). Our findings indicated that the elevated prevalence of EBV infection is not associated with the hematological diseases or transfusion rates, but with the socioeconomic status of the study population. Also, this study suggests that the EBV infection and its coinfection with CMV are related to the increase of serum ferritin levels. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
DOI: | 10.3390/biom11081151 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Tamanho | Formato | |
---|---|---|---|
Epidemiological.pdf | 402,45 kB | Adobe PDF | Visualizar/Abrir |
Este item está licenciada sob uma Licença Creative Commons