Use este identificador para citar ou linkar para este item: http://repositorio.inpa.gov.br/handle/123/2434
Título: The Genome of Anopheles darlingi, the main neotropical malaria vector
Autor(es): MARINOTTI, O.
CERQUEIRA, G. C.
DE ALMEIDA, L. G. P.
FERRO, M. I. T.
LORETO, E. L. D. S.
ZAHA, A.
TEIXEIRA, S. M. R.
WESPISER, A. R.
ALMEIDA E SILVA, A.
SCHLINDWEIN, A. D.
PACHECO, A. C. L.
DA SILVA, A. L. D. C.
GRAVELEY, B. R.
WALENZ, B. P.
DE ARAUJO LIMA, B.
RIBEIRO, C. A. G.
Carlos Gustavo Nunes-Silva
DE CARVALHO, C. R.
DE ALMEIDA SOARES, C. M.
DE MENEZES, C. B. A.
MATIOLLI, C.
CAFFREY, D.
ARAUJO, D. A. M.
DE OLIVEIRA, D. M.
GOLENBOCK, D.
GRISARD, E. C.
FANTINATTI-GARBOGGINI, F.
DE CARVALHO, F. M.
BARCELLOS, F. G.
PROSDOCIMI, F.
MAY, G.
DE AZEVEDO, G. M.
GUIMARAES, G. M.
GOLDMAN, G. H.
PADILHA, I. Q. M.
Jacqueline da Silva Batista
FERRO, J. A.
RIBEIRO, J. M. C.
FIETTO, J. L. R.
DABBAS, K. M.
CERDEIRA, L.
AGNEZ-LIMA, L. F.
BROCCHI, M.
DE CARVALHO, M. O.
TEIXEIRA, M. D. M.
DE MASCENA DINIZ MAIA, M.
GOLDMAN, M. H. S.
CRUZ SCHNEIDER, M. P.
FELIPE, M. S. S.
HUNGRIA, M.
NICOLAS, M. F.
PEREIRA, M.
MONTES, M. A.
CANTAO, M. E.
VINCENTZ, M.
Rafael, M. S.
SILVERMAN, N.
STOCO, P. H.
SOUZA, R. C.
VICENTINI, R.
GAZZINELLI, R. T.
NEVES, R. D. O.
SILVA, R.
ASTOLFI-FILHO, S.
MACIEL, T. E. F.
URMENYI, T. P.
Tadei, W. P.
CAMARGO, E. P.
DE VASCONCELOS, A. T. R.
ISSN: 0305-1048
Revista: Nucleic Acids Research
Volume: 1
Resumo: Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors similar to 100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector-human and vector-parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi.
URI: http://repositorio.inpa.gov.br/handle/123/2434
ISSN: 0305-1048
DOI: https://dx.doi.org/10.1093/nar/gkt484
Aparece nas coleções:Coordenação de Biodiversidade (CBIO)

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