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Título: Chemical profile and biological activities of Deguelia duckeana A.M.G. Azevedo (Fabaceae)
Autor(es): Nerilson Marques Lima
Jaqueline Inês Alves de Andrade
Karen C. S. Lima
Francislani Nascimento dos Santos
Andersson Barison
Kahlil S. Salomé
Takeshi Matsuura
Cecilia Veronica Nunez
Assunto: bioprospecção
ISSN: 1478-6427
Revista: Natural Product Research
Volume: 27
Resumo: Deguelia duckeana is popularly known as timbó and used by indigenous people as ictiotoxic. On account of there being no literature pertaining to the chemical profile or biological activity of this plant, the hexane, methanol and aqueous crude extracts from leaves, stems and roots were assayed that presented very high cytotoxic potential against Artemia salina, achieving 100% mortality in up to 5.0 µg mL−1 concentration, but lower antioxidant potential on 2,2-diphenyl-1-picryl-hydrazyl and Fe3+/Phenanthroline assays. The phytochemical analysis of crude extracts showed the presence of flavonoids and related compounds as major constituents as well as steroids in all of them, and tannins in polar extracts. All the extracts were assayed for antibacterial activity but only the hexane extract of stems showed moderate activity on Staphylococcus aureus, which was fractionated and yielded a mixture of 3,5,4′-trimethoxy-4-prenylstilbene, lonchocarpine, 4-hydroxylonchocarpine and derricidine, reported for the first time in D. duckeana and other fraction with β-sitosterol and stigmasterol mixture.
ISSN: 1478-6427
Aparece nas coleções:Coordenação de Tecnologia e Inovação (COTI)

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