Use este identificador para citar ou linkar para este item: http://repositorio.inpa.gov.br/handle/123/3869
Título: In vivo and in vitro antimalarial activity of 4-nerolidylcatechol
Autor(es): Luiz Francisco Rocha e Silva
Monica Regina Farias Costa
Maria das Graças Costa Alecrim
Valter Ferreira Andrade Neto
Ana Cristina da Silva Pinto
Adrian Martin Pohlit
Etienne Louis Jacques Quignard
Pedro Paulo Ribeiro Vieira
Wanderli Pedro Tadei
Francisco Célio Maia Chaves
Jean F.V. Samonek
Carlos Alberto Jatoba Lima
Assunto: Plasmodium falciparum
Plasmodium berghei
4-nerolidilcatecol
ISSN: 0951-418X
Revista: PTR. Phytotherapy Research
Volume: 25
Resumo: Nerolidylcatechol (4-NC) isolated from Piper peltatum L. (Piperaceae) was evaluated for in vitro antiplasmodial activity against Plasmodium falciparum (cultures of both standard CQR (K1) and CQS (3D7) strains and two Amazonian field isolates) and for in vivo antimalarial activity using the Plasmodium berghei-murine model. 4-NC exhibits significant in vitro and moderate in vivo antiplasmodial activity. 4-NC administered orally and subcutaneously at doses of 200, 400 and 600 mg/kg/day suppressed the growth of P. berghei by up to 63% after four daily treatments (days 1–4). Also, 4-NC exhibited important in vitro antiplasmodial activity against both standard and field P. falciparum strains in which 50% inhibition of parasite growth (IC50) was produced at concentrations of 0.05–2.11 μg/mL and depended upon the parasite strain. Interestingly, healthy (non-infected) mice that received 4-NC orally presented (denatured) blood plasma which exhibited significant in vitro activity against P. falciparum. This is evidence that mouse metabolism allows 4-NC or active metabolites to enter the blood. Further chemical and pharmacological studies are necessary to confirm the potential of 4-NC as a new antimalarial prototype. Copyright © 2011 John Wiley & Sons, Ltd.
URI: http://repositorio.inpa.gov.br/handle/123/3869
ISSN: 0951-418X
DOI: https://dx.doi.org/10.1002/ptr.3424
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