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dc.contributor.authorLuiz Francisco Rocha e Silva
dc.contributor.authorMonica Regina Farias Costa
dc.contributor.authorMaria das Graças Costa Alecrim
dc.contributor.authorValter Ferreira Andrade Neto
dc.contributor.authorAna Cristina da Silva Pinto
dc.contributor.authorAdrian Martin Pohlit
dc.contributor.authorEtienne Louis Jacques Quignard
dc.contributor.authorPedro Paulo Ribeiro Vieira
dc.contributor.authorWanderli Pedro Tadei
dc.contributor.authorFrancisco Célio Maia Chaves
dc.contributor.authorJean F.V. Samonek
dc.contributor.authorCarlos Alberto Jatoba Lima
dc.description.abstractNerolidylcatechol (4-NC) isolated from Piper peltatum L. (Piperaceae) was evaluated for in vitro antiplasmodial activity against Plasmodium falciparum (cultures of both standard CQR (K1) and CQS (3D7) strains and two Amazonian field isolates) and for in vivo antimalarial activity using the Plasmodium berghei-murine model. 4-NC exhibits significant in vitro and moderate in vivo antiplasmodial activity. 4-NC administered orally and subcutaneously at doses of 200, 400 and 600 mg/kg/day suppressed the growth of P. berghei by up to 63% after four daily treatments (days 1–4). Also, 4-NC exhibited important in vitro antiplasmodial activity against both standard and field P. falciparum strains in which 50% inhibition of parasite growth (IC50) was produced at concentrations of 0.05–2.11 μg/mL and depended upon the parasite strain. Interestingly, healthy (non-infected) mice that received 4-NC orally presented (denatured) blood plasma which exhibited significant in vitro activity against P. falciparum. This is evidence that mouse metabolism allows 4-NC or active metabolites to enter the blood. Further chemical and pharmacological studies are necessary to confirm the potential of 4-NC as a new antimalarial prototype. Copyright © 2011 John Wiley & Sons, Ltd.
dc.subjectPlasmodium falciparum
dc.subjectPlasmodium berghei
dc.titleIn vivo and in vitro antimalarial activity of 4-nerolidylcatechol
dc.publisher.periodicoPTR. Phytotherapy Research
Aparece nas coleções:Coordenação de Tecnologia e Inovação (COTI)

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