Use este identificador para citar ou linkar para este item: http://repositorio.inpa.gov.br/handle/123/3915
Título: Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives
Autor(es): Paula F. Carneiro
Emerson Silva Lima
Adrian Martin Pohlit
Vitor F. Ferreira
Maria C. R. F. Pinto
Roberta K. F. Marra
Fernando de C. da Silva
Jackson A. L. C. Resende
Luiz Francisco Rocha e Silva
Hilkem Gomes Alves
Gleyce S. Barbosa
Marne Carvalho de Vasconcellos
Assunto: quinona
oxirano
naftoquinona
ISSN: 0223-5234
Revista: European Journal of Medicinal Chemistry
Volume: 108
Resumo: A series of eighteen quinones and structurally-related oxiranes were synthesized and evaluated for in vitro inhibitory activity against the chloroquine-sensitive 3D7 clone of the human malaria parasite Plasmodium falciparum. 2-amino and 2-allyloxynaphthoquinones exhibited important antiplasmodial activity (median inhibitory concentrations (IC50) < 10 μM). Oxiranes 6 and 25, prepared respectively by reaction of α-lapachone and tetrachloro-p-quinone with diazomethane in a mixture of ether and ethanol, exhibited the highest antiplasmodial activity and low cytotoxicity against human fibroblasts (MCR-5 cell line). The active compounds could represent a good prototype for an antimalarial lead molecule.
URI: http://repositorio.inpa.gov.br/handle/123/3915
ISSN: 0223-5234
DOI: https://dx.doi.org/10.1016/j.ejmech.2015.11.020
Aparece nas coleções:Coordenação de Tecnologia e Inovação (COTI)

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