Use este identificador para citar ou linkar para este item: http://repositorio.inpa.gov.br/handle/123/4835
Título: In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants
Autor(es): Valter F de Andrade-Neto
Adrian Martin Pohlit
Ana Cristina da Silva Pinto
Ellen Cristina Costa Silva
Karla L Nogueira
Márcia Rubia S Melo
Marycleuma Campos Henrique
Luiz Francisco Rocha Silva
Mônica R F Costa
Rita de Cássia Saraiva Nunomura
Wilson D Alecrim
Maria das Graças C Alecrim
Pedro Paulo R Vieira
Sergio Massayoshi Nunomura
Assunto: Aspidosperma spp
aspidocarpine
ellipticine
ISSN: 1678-8060
Revista: Memórias do Instituto Oswaldo Cruz
Volume: 102
Resumo: In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.
URI: http://repositorio.inpa.gov.br/handle/123/4835
ISSN: 1678-8060
DOI: https://dx.doi.org/10.1590/S0074-02762007000300016
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