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Título: Evolutionary trends of LDH isozymes in fishes
Autor(es): Vera Maria Fonseca de Almeida e Val
Adalberto Luis Val
Assunto: Amazônia
Lactato Desidrogenase
ISSN: 1096-4959
Revista: Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology
Volume: 105B
Resumo: 1. LDH characteristics (loci numbers, number of isozymes constituted by A and B subunits, and tissue specificity of LDH-C4) were reviewed for 245 fish species. 2. The occurrence of different isozyme numbers among species of a single family (e.g. 3, 4 and 5 banded patterns), plus the existence of alleles generating 4 or 5 banded patterns in a single population indicate that the number of LDH isozymes constituted by A and B subunits might not be a character under selective pressure. 3. The regulatory pattern of LDH-C∗ gene, i.e. its occurrence in several tissues of primitive fishes plus its highly restricted tissue distribution in advanced teleost, and even its absence in some intermediate groups (e.g. Characiformes and Siluriformes) suggest a possible selective pressure upon an ancient gene. 4. Four evolutionary trends are suggested considering isozyme tissue distribution as well as LDH physiological role: (i) convergence of B to A subunit as in good anaerobes; (ii) restriction of B subunits in advanced teleost, resulting in the same pattern as in (i); (iii) non-divergence between A and B subunit as occurs in some Amazon fishes which are obligatory aerobes and (iv) the restriction of C subunit to specific tissues in advanced teleost reaching a high specialization degree, which physiological meaning is not explained yet.
ISSN: 1096-4959
Aparece nas coleções:Coordenação de Biodiversidade (CBIO)

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