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Confirmed invasive pulmonary aspergillosis and COVID-19: The value of postmortem findings to support antemortem management
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We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically. © 2020, Sociedade Brasileira de Medicina Tropical. All rights reserved.
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azithromycin, C reactive protein, ceftriaxone, chloroquine, creatinine, enoxaparin, furosemide, internal transcribed spacer 1, internal transcribed spacer 2, noradrenalin, oseltamivir, ribosome DNA, urea, vasoactive agent, Aged, Article, artificial ventilation, Aspergillus, Aspergillus penicillioides, Autopsy, bradycardia, bronchopneumonia, case report, clinical article, coronavirus disease 2019, cyanosis, endotracheal intubation, hematocrit, histopathology, human, human tissue, hypotension, invasive aspergillosis, lung infiltrate, lymphocytopenia, Male, neutrophilia, nucleotide sequence, polymerase chain reaction, positive end expiratory pressure, real time reverse transcription polymerase chain reaction, thorax radiography, Autopsy, Betacoronavirus, complication, Coronavirus infection, fatality, Genetics, invasive aspergillosis, isolation and purification, Lung, microbiology, pandemic, pathology, virus pneumonia, Aged, Aspergillus, Autopsy, Betacoronavirus, Coronavirus Infections, Fatal Outcome, Humans, Invasive Pulmonary Aspergillosis, Lung, Male, Pandemics, Pneumonia, Viral
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