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https://repositorio.inpa.gov.br/handle/1/15774
Título: | Prevalence of human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil |
Autor: | Morais, Márcia Poinho Encarnação de Gato, Cynara Melo Maciel, Lucinei Alves Lalwani, Pritesh Costa, Cristóvão Alves Lalwani, Jaila Dias Borges |
Palavras-chave: | Adult Blood Donor Cross-sectional Study Enzyme-linked Immunosorbent Assay Female Htlv-1 Infection Htlv-2 Infection Human Human T-lymphotropic Virus 1 Major Clinical Study Male Primate T-lymphotropic Virus 2 Seroprevalence Social Status Structured Questionnaire Western Blotting Adolescent Blood Donor Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Isolation And Purification Middle Aged Prevalence Seroepidemiology Statistics And Numerical Data Virology Young Adult Adolescent Adult Blood Donors Western Blotting Cross-sectional Studies Enzyme-linked Immunosorbent Assay Female Htlv-ii Infections Htlv-ii Infections Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Humans Male Middle Aged Prevalence Seroepidemiologic Studies Young Adult |
Data do documento: | 2017 |
Revista: | Revista do Instituto de Medicina Tropical de Sao Paulo |
É parte de: | Volume 59 |
Abstract: | Introduction: Human T-lymphotropic virus type 1 and 2 (HTLV-1/2) is endemic in Brazil, but few studies have investigated the seroprevalence of HTLV and its subtypes among blood donors in the capital city Manaus, Amazonas State, Brazil. Aim: To estimate the seroprevalence of HTLV-1/2 and to identify circulating subtypes among blood donors in Manaus. Materials and Methods: Blood donors (2001-2003) were screened for HTLV-1/2 antibodies by ELISA. Positive results were confirmed and subtyped by Western blot assays. Prevalence rates were calculated and compared with demographic data. Results: Among the 87,402 individuals screened, 116 (0.13%) were seropositive for HTLV-1/2. A second sample (76/116) was collected and retested by HTLV-1/2 ELISA, of which only 41/76 were positive. Western blot confirmed HTLV infection in 24/41 retested blood donors [HTLV-1 (n=16), HTLV-2 (n=5) and HTLV-untypable (n=3)]. Discussion: HTLV-1 and HTLV-2 are prevalent among blood donors in Manaus. However, additional studies are needed to comprehend the epidemiology of HTLV-1/2 in Amazonas not only to understand the pathophysiology of the disease providing adequate medical assistance, but also to reduce or block virus transmission. © 2017, Instituto de Medicina Tropical de Sao Paulo. All rights reserved. |
DOI: | 10.1590/S1678-9946201759080 |
Aparece nas coleções: | Artigos |
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