Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/16139
Title: Anti-inflammatory, anti-hyperalgesic, antiplatelet and antiulcer activities of Byrsonima japurensis A. Juss. (Malpighiaceae)
Authors: Guilhon-Simplicio, Fernanda
Pinheiro, Carlos Cleomir de Souza
Conrado, Gabrielly Galdino
Barbosa, Gleyce dos Santos
Santos, Pierre Alexandre dos
Pereira, Maria de Meneses
Lima, Emerson Silva
Keywords: Analgesic Agent
Antiinflammatory Agent
Antithrombocytic Agent
Antiulcer Agent
Beta Carotene
Byrsonima Japurensis Extract
Indometacin
Plant Extract
Superoxide
Unclassified Drug
Analgesic Activity
Animals Model
Anticoagulation
Antiinflammatory Activity
Antioxidant Activity
Antiulcer Activity
Bark
Bleaching
Blood Analysis
Clinical Evaluation
Concentration Response
Controlled Study
Dose Response
Drug Megadose
Drug Safety
Drug Screening
Female
Human
Human Tissue
Ic 50
In Vitro Study
Male
Malpighiaceae
Mouse
Nonhuman
Plant Stem
Rat
Medicine, Traditional
Analgesics
Animal
Anti-inflammatory Agents
Anti-inflammatory Agents, Non-steroidal
Anti-ulcer Agents
Antioxidants
Beta Carotene
Carrageenan
Edema
Female
Humans
Male
Malpighiaceae
Mice
Mice, Inbred Balb C
Pain
Phytotherapy
Plant Bark
Plant Extracts
Plant Stems
Platelet Aggregation Inhibitors
Rats
Rats, Wistar
Stomach Ulcer
Superoxides
Byrsonima
Malpighiaceae
Mus
Rattus
Rattus Norvegicus
Issue Date: 2012
metadata.dc.publisher.journal: Journal of Ethnopharmacology
metadata.dc.relation.ispartof: Volume 140, Número 2, Pags. 282-286
Abstract: Ethnopharmacological relevance: Decoctions or infusions of the stem bark of Byrsonima japurensis A. Juss. (Malpighiaceae) are widely used as an anti-inflammatory drug in folk medicine of Amazonas State (Brazil). Aim of the study: To evaluate the pharmacological potential of an aqueous extract of the stem bark of Byrsonima japurensis (BJEA) to scientifically verify of its traditional use. Materials and methods: Anti-inflammatory, antihyperalgesic and antiulcer activities were evaluated in Wistar rats, a Hippocratic screening was performed in Swiss mice to evaluate the toxic effects, and antiplatelet evaluation was performed in human platelet rich plasma assay. Additionally, antioxidant activity was evaluated by superoxide radical scavenging method and β-carotene bleaching test. Results: Anti-inflammatory, antihyperalgesic and gastroprotective activities were observed in rats treated orally with different doses of BJEA. While signals of toxicity were observed in the mice treated with a very high dose of extract (5000 mg/kg), no death occurred. BJEA also showed expressive antiplatelet and antioxidant activities in vitro. Conclusion: According to our results, it was concluded that stem bark of Byrsonima japurensis has significant and safe anti-inflammatory activity, which is closely related with their potent antioxidant activity, supporting the folk medicinal use of this species. Crown Copyright © 2012 Published by Elsevier Ireland Ltd. All rights reserved.
metadata.dc.identifier.doi: 10.1016/j.jep.2012.01.018
Appears in Collections:Artigos

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