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Título: | Effects of a Mikania laevigata extract on bone resorption and RANKL expression during experimental periodontitis in rats |
Autor: | Benatti, B. B. Campos-Júnior, Jozafá C. Silva-Filho, Vilmar J. Alves, Polyanna Miranda Rodrigues, Isabela R. Uber-Bucek, Elizabeth Manfredo Vieira, Silvio Napimoga, Marcelo Henrique |
Data do documento: | 2012 |
Revista: | Journal of Applied Oral Science |
É parte de: | Volume 20, Número 3, Pags. 340-346 |
Abstract: | Objectives: The Mikania laevigata extract (MLE) (popularly known in Brazil as "guaco") possesses anti-inflammatory properties. In the present study we tested the effects of MLE in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying such effects. Material and Methods: Periodontal disease was induced by a ligature placed around the mandibular first molars of each animal. Male Wistar rats were divided into 4 groups: non-ligated animals treated with vehicle; non-ligated animals treated with MLE (10 mg/kg, daily); ligature-induced animals treated with vehicle and ligature-induced animals treated with MLE (10 mg/kg, daily). Thirty days after the induction of periodontal disease, the animals were euthanized and mandibles and gingival tissues removed for further analysis. Results: Morphometric analysis of alveolar bone loss demonstrated that MLE-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-κB ligand (RANKL) measured by immunohistochemistry. Moreover, gingival tissues from the MLE-treated group showed decreased neutrophil migration myeloperoxidase (MPO) assay. Conclusions: These results indicate that MLE may be useful to control bone resorption during progression of experimental periodontitis in rats. |
DOI: | 10.1590/S1678-77572012000300008 |
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