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https://repositorio.inpa.gov.br/handle/1/16300| Title: | Chemical constituents from the roots of Spathelia excelsa and their antiprotozoal activity |
| Authors: | Moreira, Wagner Alan dos Santos Lima, Maria da Paz Ferreira, Antonio Gilberto Piloto Ferreira, Izabel Cristina Nakamura, Celso Vataru |
| Issue Date: | 2009 |
| metadata.dc.publisher.journal: | Journal of the Brazilian Chemical Society |
| metadata.dc.relation.ispartof: | Volume 20, Número 6, Pags. 1089-1094 |
| Abstract: | Phytochemical investigation from roots of Spathelia excelsa yielded the chromones 10(2,3-epoxy-3-methylbutanyl)spatheliachromen and 10(2,3-dihydroxy-3-methylbutanyl) methoxyspatheliacromen (5-methoxyspatheliabischromen); limonoid deacetylspathelin and protolimonoid C-21-epimers 3β-angeloyloxy-7α,24,25-trihydroxy-21,23-oxide-14,18-cycloapotirucall-21-hemiacetal; the alkaloids 7,8-dimethoxyflindersin, casimiroin and N-methyl-4,7,8-trimethoxyquinolin-2(1H)-one, besides a mixture of β-sitosterol and stigmasterol. Assays on promastigote forms of Leishmania braziliensis, deacetylspathelin showed moderate activity; and on epimastigote forms of Trypanossoma cruzi, 10(2,3-epoxy-3-methylbutanyl)spatheliachromen exhibited strong activity (IC50 = 11 μg mL-1). ©2009 Sociedade Brasileira de Química. |
| Appears in Collections: | Artigos |
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