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Title: | Productivity and bioactivity of enokipodins A–D of Flammulina rossica and Flammulina velutipes |
Authors: | Tabuchi, Akiko Fukushima-Sakuno, Emi Osaki-Oka, Kumiko Futamura, Yushi Motoyama, Takayuki Osada, Hiroyuki Ishikawa, Noemia Kazue Nagasawa, Eiji Tokimoto, Keisuke |
Keywords: | Bacteriology Bioactivity Cell Culture Fungi Anti-proliferative Activities Enokipodins Flammulina Rossica Flammulina Velutipes Inhibitory Activity Malarial Parasites Plant Pathogenic Fungus Plasmodium Falciparum Productivity |
Issue Date: | 2020 |
metadata.dc.publisher.journal: | Bioscience, Biotechnology and Biochemistry |
Abstract: | Enokipodins are antimicrobial sesquiterpenes produced by Flammulina velutipes in a mycelial culture medium. To date, enokipodin production has not been reported in other members of the genus Flammulina. Hence, in this study, the production of enokipodins A, B, C, and D by F. velutipes and F. rossica was investigated. Some strains of F. rossica were confirmed to produce at least one of the four enokipodins in the culture medium. However, some strains of F. velutipes did not produce any of the enokipodins. In an antibacterial assay using liquid medium, enokipodin B showed the strongest growth inhibitory activity against Bacillus subtilis among the four types of enokipodins. Enokipodin B inhibited the spore germination of some plant pathogenic fungi. Enokipodins B and D exerted moderate anti-proliferative activity against some cancer cell lines, and enokipodins A and C inhibited the proliferation of the malarial parasite, Plasmodium falciparum. © 2020, © 2020 Japan Society for Bioscience, Biotechnology, and Agrochemistry. |
metadata.dc.identifier.doi: | 10.1080/09168451.2020.1714421 |
Appears in Collections: | Artigos |
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