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https://repositorio.inpa.gov.br/handle/1/16758| Title: | Cross-reactivity between Potamotrygon motoro antivenoms and dorsal and stinger extracts of others stingrays (Chondrichthyes: Potamotrygonidae) from the Amazon basin |
| Authors: | Lameiras, Juliana Luiza Varjão Moura, Valéria Mourão de Dias, Lucas Castanhola Santos, Ilia Gilmara Carvalho dos Costa, Oscar Tadeu Ferreira da Santos, Maria Cristina dos |
| Keywords: | Fish Venom Tissue Extract Antibody Production Antigen Antibody Reaction Cartilaginous Fish Cross Reaction Dorsal Region Envenomation Enzyme-linked Immunosorbent Assay Nonhuman Paratrygon Aiereba Plesiotrygon Iwamae Potamotrygon Motoro Potamotrygon Orbignyi Potamotrygon Schroederi Western Blotting |
| Issue Date: | 2019 |
| metadata.dc.publisher.journal: | Toxin Reviews |
| metadata.dc.relation.ispartof: | Volume 38, Número 1, Pags. 61-70 |
| Abstract: | In this study, two mouse hyperimmune sera were produced, one using extract from the stinger of the stingray Potamotrygon motoro and the other using extract from the dorsal region of the same species and their cross-reactivity with extracts from the following species of stingrays from the Amazon basin was investigated using Western blot and dot ELISA: Paratrygon aiereba, Plesiotrygon iwamae, Potamotrygon orbignyi and Potamotrygon schroederi. The results show that the dorsal extract was as immunogenic as the stinger extract and induced high levels of antibodies, which reacted with homologous and heterologous antigens, indicating that both types of extract may be suitable for use in the production of antivenom to treat victims of envenomation by stingrays. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. |
| metadata.dc.identifier.doi: | 10.1080/15569543.2017.1394324 |
| Appears in Collections: | Artigos |
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