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https://repositorio.inpa.gov.br/handle/1/17332
Title: | Structure and antinociceptive effects of β-d-glucans from Cookeina tricholoma |
Authors: | Moreno, Roberta Barbara Ruthes, Andrea Caroline Baggio, C. H. Vilaplana, Francisco Komura, Dirce Leimi Iacomini, Marcello |
Keywords: | Chains Fungi Antinociceptive Effect Ascomycete Brazilian Amazon Cookeina Tricholoma Extractability Glucans Substitution Patterns Wild Edible Mushrooms Polysaccharides Analgesic Agent Fungal Polysaccharide Glucan Animals Ascomycetes Chemistry Drug Effects Female Mouse Nociception Analgesics Animal Ascomycota Female Fungal Polysaccharides Glucans Mice Nociception |
Issue Date: | 2016 |
metadata.dc.publisher.journal: | Carbohydrate Polymers |
metadata.dc.relation.ispartof: | Volume 141, Pags. 220-228 |
Abstract: | Structurally different water-insoluble (1 → 3),(1 → 6) β-d-glucans were isolated from aqueous and alkaline extracts of the mushroom-forming ascomycete Cookeina tricholoma, a wild edible mushroom found in Brazilian Amazon forest. The structures showed different substitution patterns, which may influence their extractability and consequently their conformation in solution, and different MW (4.3 × 105 Da, 3.7 × 105 Da and 8.2 × 105 Da, for ICW-Ct, IHW-Ct and IK2-Ct, respectively). The main-chains are composed of (1 → 3)-linked β-d-Glcp units O-6 substituted by side chains with different lengths of (1 → 6)-linked β-d-Glcp units (ICW-Ct and IHW-Ct) or by a combination of (1 → 6)-linked β-d-Glcp units and single units of β-d-Glcp (IK2-Ct). β-d-glucans with similar MW and showing only (1 → 6)-linked β-d-Glcp units as side chains (ICW-Ct and IHW-Ct) showed significant inhibition of neurogenic pain, 69 ± 11 and 57 ± 11% at the dose of 10 mg kg-1, respectively, in the model of nociception induced by intraplantar injection of formalin. © 2016 Published by Elsevier Ltd. |
metadata.dc.identifier.doi: | 10.1016/j.carbpol.2016.01.001 |
Appears in Collections: | Artigos |
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