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https://repositorio.inpa.gov.br/handle/1/17493
Title: | Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil |
Authors: | Silva, George Allan Villarouco da Ramasawmy, Rajendranath Boechat, Antonio Luiz Morais, A. C. Carvalho, B. K.S. Sousa, K. B A Souza, V. C. Cunha, Maria Coelho Graça Souza Barletta-Naveca, Raphaela Honorato Santos, M. P. Naveca, Felipe Gomes |
Keywords: | Dna Nucleotide Tumor Necrosis Factor Biological Marker Tumor Necrosis Factor-alpha Amazona Controlled Study Female Gene Frequency Genetic Association Genotype Host Susceptibility Human Leprosy Major Clinical Study Male Outcome Assessment Priority Journal Promoter Region Polymorphism, Single Nucleotide Disease Course Genetic Association Genetic Predisposition Genetics Genotype Immunology Leprosy Metabolism Mycobacterium Leprae Nucleotide Sequence Predictive Value Promoter Region Biomarkers Disease Progression Dna Mutational Analysis Gene Frequency Genetic Association Studies Genetic Predisposition To Disease Genotype Humans Leprosy Mycobacterium Leprae Polymorphism, Single Nucleotide Predictive Value Of Tests Promoter Regions, Genetic Tumor Necrosis Factor-alpha |
Issue Date: | 2015 |
metadata.dc.publisher.journal: | Human Immunology |
metadata.dc.relation.ispartof: | Volume 76, Número 2-3, Pags. 137-141 |
Abstract: | Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation. Nucleotide sequencing was performed with DNA samples from 108 leprosy patients and 253 control subjects. An association between -1031 C/C genotype and protection from leprosy was observed when leprosy patients were compared to controls (OR 0.11; 95% CI. =. 0.01-0.82; p=. 0.012). The -857 C/T genotype may be associated with susceptibility to leprosy (OR. =. 1.81; 95% CI. =. 1.09-3.00; p=. 0.028). Similar genotype and allele frequencies for the SNPs -308 G/A and -238 G/A were observed between leprosy patients and control subjects. Altogether, TNF polymorphisms in the promoter region may be predictive of leprosy outcome. © 2015 American Society for Histocompatibility and Immunogenetics. |
metadata.dc.identifier.doi: | 10.1016/j.humimm.2015.01.011 |
Appears in Collections: | Artigos |
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