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https://repositorio.inpa.gov.br/handle/1/17593| Title: | Insecticidal and genotoxic potential of two semi-synthetic derivatives of dillapiole for the control of Aedes (Stegomyia) aegypti (Diptera: Culicidae) |
| Authors: | Domingos, Pedro Rauel Cândido Pinto, Ana Cristina da Silva Santos, Joselita Maria Mendes dos Rafael, Míriam Silva |
| Keywords: | Dill Apiole Dill Apiole Derivative Larvicidal Agent Unclassified Drug 1,3 Dioxolane Derivative 5-allyl 6,7-dimethoxy 1,3-benzodioxole Allyl Compound Insecticide Adult Aedes Aegypti Cell Division Controlled Study Cytotoxicity Egg Laying Female Genotoxicity Insecticidal Activity Interphase Larva Lc50 Neuroblast Nonhuman Oocyte Priority Journal Vector Control Aedes Animals Chemistry Dengue Virus Disease Carrier Dna Damage Metabolism Synthesis Virology Aedes Allyl Compounds Animal Dengue Virus Dioxoles Dna Damage Insect Vectors Insecticides |
| Issue Date: | 2014 |
| metadata.dc.publisher.journal: | Mutation Research - Genetic Toxicology and Environmental Mutagenesis |
| metadata.dc.relation.ispartof: | Volume 772, Pags. 42-54 |
| Abstract: | The effects of two semi-synthetic dillapiole derivatives, ethyl-ether dillapiole and n-butyl ether dillapiole, on eggs and larvae of Aedes aegypti were studied in view of the need for expansion and renovation of strategic action to control this mosquito - the vector of Dengue virus -, which currently shows a high resistance to chemical insecticides. Eggs and third-instar larvae of A. aegypti that had been exposed to different concentrations of these two compounds showed toxicity and susceptibility, with 100% mortality. Classical cytogenetic assays showed genotoxicity caused by the two compounds in A. aegypti from the cumulative effect of nuclear abnormalities, indicating that these derivatives may be potential alternatives to control A. aegypti. © 2014. |
| metadata.dc.identifier.doi: | 10.1016/j.mrgentox.2014.07.008 |
| Appears in Collections: | Artigos |
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