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https://repositorio.inpa.gov.br/handle/1/17843| Title: | Isolation and identification of α-glucosidase, α-amylase and lipase inhibitors from Hortia longifolia |
| Authors: | Queiroz, Darlene P.K. Ferreira, Antonio Gilberto Lima, Arleilson Sousa Lima, Emerson Silva Lima, Maria da Paz |
| Keywords: | Acarbose Alpha Glucosidase Amide Amylase Cinnamic Acid Derivative Coumarin Ferulic Acid Hortia Longifolia Extract Limonin Plant Extract Scopoletin Skimmianine Triacylglycerol Lipase Unclassified Drug Carbon Nuclear Magnetic Resonance Column Chromatography Controlled Study Correlation Analysis Drug Identification Drug Isolation Enzymatic Assay Extraction Fractionation Hortia Longifolia Ic 50 Nonhuman Plant Proton Nuclear Magnetic Resonance Chromatography, Thin Layer |
| Issue Date: | 2013 |
| metadata.dc.publisher.journal: | International Journal of Pharmacy and Pharmaceutical Sciences |
| metadata.dc.relation.ispartof: | Volume 5, Número 3, Pags. 336-339 |
| Abstract: | Phytochemical investigation from branches of Hortia longifolia (Rutaceae) yielded the amide N-[2-(4-prenyloxyphenyl)ethyl]tigliamide (1), (E)-methyl-O-prenyl ferulate (2), limonin (3), cinnamic acid derivatives [(E)-methyl-5'-hydroxy-O-prenyl cinnamate 4 and integrifoliodiol 7], scopoletin (5) and skimmianine (6). The compound 4 showed moderate α-amylase inhibitory activity, the coumarin 5 presented strong activity on α-glucosidase (IC50 of 0.89 μg/mL). The compounds 1, 2, 4 and 5 exhibited significant inhibitory activity on lipase with IC50 at 6.91, 8.14, 3.86 and 5.07 μg/mL, respectively. The results demonstrate potential use for these compounds in development of drugs of natural origin in the prevention or treatment of metabolic syndrome. |
| Appears in Collections: | Artigos |
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