Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/18054
Título: The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases - Part II
Autor: Schmidt, Thomas Jürgen
Khalid, Sami A.
Romanha, Álvaro José
Alves, Tânia Maria de Almeida
Biavatti, Maique Weber
Brun, Reto
Costa, Fernando Batista da
De-Castro, Solange Lisboa
Ferreira, V?tor Francisco
Lacerda, Marcus Vinícius Guimarães de
Lago, João Henriqu Ghilardi
Leon, Leonor Laura Pinto
Lopes, Norberto Peporine
Amorim, Rodrigo César das Neves
Niehues, Michael
Ogungbe, Ifedayo Victor
Pohlit, Adrian Martin
Scotti, M. T.
Setzer, William N.
Soeiro, M. N.C. de
Steindel, Mário R.
Tempone, Andre Gustavo
Palavras-chave: Acridone Derivative
Alizarin
Aloe Emodin
Antileishmanial Agent
Beta Lapachone
Caffeic Acid Derivative
Coumarin
Diospyrin
Diprophylline
Emodin
Galgravin
Juglone
Kaempferol
Lapachol
Lawsone
Lignan
Luteolin
Neolignan
Nordihydroguaiaretic Acid
Phytomenadione
Plant Extract
Plastoquinone
Plumbagin
Purpurin
Scopoletin
Stibogluconate Sodium
Thamnosma Rhodesica
Toddalia Asiatica Extract
Ubiquinone
Unclassified Drug
Unindexed Drug
African Trypanosomiasis
Antiprotozoal Activity
Aristolochiaceae
Calophyllaceae
Chagas Disease
Clausena
Epimastigote
Human
In Vitro Study
Leishmaniasis
Medicinal Plant
Nonhuman
Rutaceae
Tropical Disease
Trypomastigote
Animal
Antiprotozoal Agents
Biological Agents
Humans
Neglected Diseases
Phytotherapy
Plant Extracts
Plants, Medicinal
Protozoan Infections
Data do documento: 2012
Revista: Current Medicinal Chemistry
É parte de: Volume 19, Número 14, Pags. 2176-2228
Abstract: Infections with protozoan parasites are a major cause of disease and mortality in many tropical countries of the world. Diseases caused by species of the genera Trypanosoma (Human African Trypanosomiasis and Chagas Disease) and Leishmania (various forms of Leishmaniasis) are among the seventeen "Neglected Tropical Diseases" (NTDs) defined by the WHO. Furthermore, malaria (caused by various Plasmodium species) can be considered a neglected disease in certain countries and with regard to availability and affordability of the antimalarials. Living organisms, especially plants, provide an innumerable number of molecules with potential for the treatment of many serious diseases. The current review attempts to give an overview on the potential of such plant-derived natural products as antiprotozoal leads and/or drugs in the fight against NTDs. In part I, a general description of the diseases, the current state of therapy and need for new therapeuticals, assay methods and strategies applied in the search for new plant derived natural products against these diseases and an overview on natural products of terpenoid origin with antiprotozoal potential were given. The present part II compiles the current knowledge on natural products with antiprotozoal activity that are derived from the shikimate pathway (lignans, coumarins, caffeic acid derivatives), quinones of various structural classes, compounds formed via the polyketide pathways (flavonoids and related compounds, chromenes and related benzopyrans and benzofurans, xanthones, acetogenins from Annonaceae and polyacetylenes) as well as the diverse classes of alkaloids. In total, both parts compile the literature on almost 900 different plant-derived natural products and their activity data, taken from over 800 references. These data, as the result of enormous efforts of numerous research groups world-wide, illustrate that plant secondary metabolites represent an immensely rich source of chemical diversity with an extremely high potential to yield a wealth of lead structures towards new therapies for NTDs. Only a small percentage, however, of the roughly 200,000 plant species on earth have been studied chemically and only a small percentage of these plants or their constituents has been investigated for antiprotozoal activity. The repository of plant-derived natural products hence deserves to be investigated even more intensely than it has been up to present. © 2012 Bentham Science Publishers.
Aparece nas coleções:Artigos

Arquivos associados a este item:
Não existem arquivos associados a este item.


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.