Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/37745
Título: | COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence |
Autor: | Naveca, Felipe Gomes Nascimento, Valdinete Alves Do Souza, Victor Costa de Corado, André Lima Guerra Nascimento, Fernanda Oliveira Do Silva, George Allan Villarouco Da Costa, Ágatha Duarte, Débora Camila Gomes Pessoa, Karina Pinheiro Mejía, Matilde Del Carmen Contreras Brandão, Maria Júlia Jesus, Michele S. Gonçalves, Luciana Mara Fé da Costa, Cristiano Fernandes S. Sampaio, Vanderson Barros, Daniel Silva, Marineide Mattos, Tirza Pontes, Gemilson Soares Abdalla, Lígia Fernandes Santos, João Hugo Abdalla Arantes, Ighor L.G. Dezordi, Filipe Zimmer Siqueira, Marilda Mendonça Teixeira De Wallau, G. L. Resende, Paola Cristina Delatorre, Edson Oliveira Gräf, Tiago Bello, Gonzalo |
Data do documento: | 2021 |
Revista: | Nature Medicine |
Abstract: | The northern state of Amazonas is among the regions in Brazil most heavily affected by the COVID-19 epidemic and has experienced two exponentially growing waves, in early and late 2020. Through a genomic epidemiology study based on 250 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from different Amazonas municipalities sampled between March 2020 and January 2021, we reveal that the first exponential growth phase was driven mostly by the dissemination of lineage B.1.195, which was gradually replaced by lineage B.1.1.28 between May and June 2020. The second wave coincides with the emergence of the variant of concern (VOC) P.1, which evolved from a local B.1.1.28 clade in late November 2020 and replaced the parental lineage in <2 months. Our findings support the conclusion that successive lineage replacements in Amazonas were driven by a complex combination of variable levels of social distancing measures and the emergence of a more transmissible VOC P.1 virus. These data provide insights to understanding the mechanisms underlying the COVID-19 epidemic waves and the risk of dissemination of SARS-CoV-2 VOC P.1 in Brazil and, potentially, worldwide. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc. |
DOI: | 10.1038/s41591-021-01378-7 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Este item está licenciada sob uma Licença Creative Commons