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https://repositorio.inpa.gov.br/handle/1/39572
Title: | Persistence of SARS-CoV-2 Antigens in the Nasal Mucosa of Eight Patients with Inflammatory Rhinopathy for over 80 Days following Mild COVID-19 Diagnosis |
Authors: | Costa dos Santos, Juliana Ximenes Rabelo, Marjory Mattana Sebben, Luana de Souza Carneiro, Matheus Viniciu s Bosco Lopes Botelho, João Cardoso Neto, José Nogueira Barbosa, Anderson Monteiro de Carvalho, Diego Pontes, Gemilson Soares |
Keywords: | Mucosa nasal Disfunção olfativa Olfactory dysfunction Rhinopathy COVID-19 |
Issue Date: | Apr-2023 |
metadata.dc.publisher.journal: | Viruses |
metadata.dc.relation.ispartof: | Volume 15, edição 4 |
Abstract: | The nasal mucosa is the main gateway for entry, replication and elimination of the SARS-CoV-2 virus, the pathogen that causes severe acute respiratory syndrome (COVID-19). The presence of the virus in the epithelium causes damage to the nasal mucosa and compromises mucociliary clearance. The aim of this study was to investigate the presence of SARS-CoV-2 viral antigens in the nasal mucociliary mucosa of patients with a history of mild COVID-19 and persistent inflammatory rhinopathy. We evaluated eight adults without previous nasal diseases and with a history of COVID-19 and persistent olfactory dysfunction for more than 80 days after diagnosis of SARS-CoV-2 infection. Samples of the nasal mucosa were collected via brushing of the middle nasal concha. The detection of viral antigens was performed using immunofluorescence through confocal microscopy. Viral antigens were detected in the nasal mucosa of all patients. Persistent anosmia was observed in four patients. Our findings suggest that persistent SARS-CoV-2 antigens in the nasal mucosa of mild COVID-19 patients may lead to inflammatory rhinopathy and prolonged or relapsing anosmia. This study sheds light on the potential mechanisms underlying persistent symptoms of COVID-19 and highlights the importance of monitoring patients with persistent anosmia and nasal-related symptoms. |
ISSN: | 19994915 |
metadata.dc.identifier.doi: | 10.3390/v15040899 |
Appears in Collections: | Artigos |
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viruses-15-00899.pdf | 1,48 MB | Adobe PDF | View/Open |
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