Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/14691
Título: | Alleles of HLA-DRB1∗04 associated with pulmonary tuberculosis in Amazon Brazilian population |
Autor: | Lima, Dhêmerson Souza de Ogusku, Maurício Morishi Santos, Maria Cristina dos Silva, Cláudia Maria de Melo Almeida, Vanessa Alves de Antunes, Irineide Assumpção Boechat, Antonio Luiz Ramasawmy, Rajendranath Sadahiro, Aya |
Palavras-chave: | Early Secretory Antigenic Target 6 Hla Drb1 Antigen Hla Drb1 Antigen Hla-drb1*04 Antigen Adult Alcohol Consumption Allele Brazilian Controlled Study Correlation Analysis Disease Transmission Female Gender Gene Frequency Genetic Association Genetic Susceptibility Hla Drb1 Gene Human Lung Tuberculosis Major Clinical Study Male Nucleotide Sequence Polymerase Chain Reaction Prevalence Smoking Allele Polymorphism, Genetic Genetic Predisposition Genetics Lung Tuberculosis Middle Aged Young Adult Adult Alleles Female Genetic Predisposition To Disease Hla-drb1 Chains Humans Male Middle Aged Polymorphism, Genetic Tuberculosis, Pulmonary Young Adult |
Data do documento: | 2016 |
Revista: | PLoS ONE |
É parte de: | Volume 11, Número 2 |
Abstract: | Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1∗04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazilian Amazon. The HLA-DRB1∗04 was prevalent in patients with pulmonary TB (p<0.0001; OR = 2.94; 95% CI = 2.12 to 4.08). Direct nucleotide sequencing of DRB1 exon 2 identified nine subtypes of HLA-DRB1∗04. The subtype HLA-DRB1∗04:11:01 (p = 0.0019; OR = 2.23; 95% CI = 1.34 to 3.70) was associated with susceptibility to pulmonary TB while DRB1∗04:07:01 (p<0.0001; OR = 0.02; 95% CI = 0.001 to 0.33) to protection. Notably, the interaction between alcohol and HLA-DRB1∗04:11:01 increased the risk for developing pulmonary TB (p = 0.0001; OR = 51.3; 95% CI = 6.81 to 386). Multibacillary pulmonary TB, the clinical presentation of disease transmission, was strongly associated with interaction to alcohol (p = 0.0026; OR = 11.1; 95% CI = 3.99 to 30.9), HLA-DRB1∗04:11:01 (p = 0.0442; OR =2.01; 95% CI = 1.03 to 3.93) and DRB1∗04:92 (p = 0.0112; OR = 8.62; 95% CI = 1.63 to 45.5). These results show that HLA-DRB1∗04 are associated with pulmonary TB. Interestingly, three subtypes, DRB1∗04:07:01, DRB1∗04:11:01 and DRB1∗04:92 of the HLA-DRB1∗04 could be potential immunogenetic markers that may help to explain mechanisms involved in disease development. © 2016 Souza de Lima et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0147543 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
artigo-inpa.pdf | 278,1 kB | Adobe PDF | Visualizar/Abrir |
Este item está licenciada sob uma Licença Creative Commons