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dc.contributor.authorBoechat, Narjara de Oliveira-
dc.contributor.authorOgusku, Maurício Morishi-
dc.contributor.authorBoechat, Antonio Luiz-
dc.contributor.authorSadahiro, Aya-
dc.date.accessioned2020-04-24T17:00:58Z-
dc.date.available2020-04-24T17:00:58Z-
dc.date.issued2012-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/14726-
dc.description.abstractBackground: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints that affects approximately 1% of the population worldwide. The HLA-DRB1 gene locus plays a major role in genetic susceptibility to RA, a condition that has been associated with a high cardiovascular morbidity and mortality in many studies. Methodology/Principal Findings: The aim of this work was to investigate which types of HLA class II genes are associated with RA in patients from the Brazilian Amazon and their influence on high cardiovascular risk status in this population. For this purpose, a case-control study was carried out with a total of 350 non-Indian individuals made up of a cohort of 132 consecutive RA sufferers and 218 healthy controls. A χ2 test showed that HLADRB1*04 (p<0.0016; OR = 1.89; 95% CI = 1.29-2.79) and HLADRB1*10 (p = 0.0377; OR = 3.81; 95% CI = 1.16-12.50) are the major HLA genes associated with susceptibility to RA. A logistic regression model also showed that the interaction between HLADRB1*04 (p = 0.027; OR = 6.02; 95% CI = 1.21-29.7), age (p = 0.0001; OR = 1.26; 95% CI = 1.13-1.39) and smoking (p = 0.0001; OR = 23.6; 95% CI = 4.25-32.1) is associated with a probability of a high cardiovascular risk status at an early age. Conclusions/Significance: The results of this study show for the first time that HLA class II type is associated with RA in Brazilian Amazon populations and that a specific interaction between the HLA-DRB1*04 gene and smoking is associated with a high cardiovascular risk status, as initially reported in the European population. This study therefore contributes to an understanding of gene-environment interactions in RA patients. © 2012 Boechat et al.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 7, Número 8pt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectEpitopeen
dc.subjectHla Drb1 Antigenen
dc.subjectHla Drb5 Antigenen
dc.subjectAdulten
dc.subjectAlleleen
dc.subjectCardiovascular Risken
dc.subjectCase Control Studyen
dc.subjectControlled Studyen
dc.subjectDisease Activityen
dc.subjectFemaleen
dc.subjectGeneen
dc.subjectGenetic Associationen
dc.subjectGenetic Risken
dc.subjectGenetic Susceptibilityen
dc.subjectGenotype-environment Interactionen
dc.subjectHigh Risk Populationen
dc.subjectHla Drb1 Geneen
dc.subjectHla Drb5 Geneen
dc.subjectHumanen
dc.subjectMajor Clinical Studyen
dc.subjectMaleen
dc.subjectArthritis, Rheumatoiden
dc.subjectRisk Assessmenten
dc.subjectSmoking Habiten
dc.subjectTrend Studyen
dc.subjectAdulten
dc.subjectArthritis, Rheumatoiden
dc.subjectCardiovascular Diseasesen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectHla-drb1 Chainsen
dc.subjectHumansen
dc.subjectLogistic Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectRisken
dc.subjectSmokingen
dc.titleInteraction between smoking and HLA-DRB1*04 gene is associated with a high cardiovascular risk in Brazilian Amazon patients with rheumatoid arthritisen
dc.typeArtigopt_BR
dc.identifier.doi10.1371/journal.pone.0041588-
dc.publisher.journalPLoS ONEpt_BR
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