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dc.contributor.authorVal, Vera Maria Fonseca Almeida e-
dc.contributor.authorOliveira, Alice Reis-
dc.contributor.authorSilva, Maria de Nazaré Paula da-
dc.contributor.authorFerreira-Nozawa, Mônica Stropa-
dc.contributor.authorAraújo, Roziete Mendes-
dc.contributor.authorVal, Adalberto Luis-
dc.contributor.authorNozawa, Sérgio Ricardo-
dc.description.abstractAdaptation or acclimation to hypoxia occurs via the modulation of physiologically relevant genes, such aserythropoietin,transferrin, vascular endothelial growth factor, phosphofructokinase and lactate dehydrogenase A. In the present study, we have cloned, sequenced and examined the modulation of the LDH-A gene after an Amazonian fish species, Astronotus crassipinis(the Oscar), was exposed to hypoxia and anoxia. In earlier studies, we have discovered that adults of this species are extremely tolerant to hypoxia and anoxia, while the juveniles are less tolerant. Exposure of juveniles to acute hypoxia and anoxia resulted in increased LDH-A gene expression in skeletal and cardiac muscles. When exposed to graded hypoxia juveniles show decreased LDH-A expression. In adults, the levels of LDH-A mRNA did not increase in hypoxic or anoxic conditions. Our results demonstrate that, when given time for acclimation, fish at different life-stages are able to respond differently to survive hypoxic episodes. © 2011, Sociedade Brasileira de Genética.en
dc.relation.ispartofVolume 34, Número 2, Pags. 315-322pt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.subjectLactate Dehydrogenaseen
dc.subjectLactate Dehydrogenase Isoenzyme 5en
dc.subjectRna, Messengeren
dc.subjectUnclassified Drugen
dc.subjectAnimals Experimenten
dc.subjectAnimals Tissueen
dc.subjectAstronotus Crassipinisen
dc.subjectControlled Studyen
dc.subjectGene Expressionen
dc.subjectGene Sequenceen
dc.subjectHeart Muscleen
dc.subjectLdh A Geneen
dc.subjectCloning, Molecularen
dc.subjectNucleotide Sequenceen
dc.subjectMuscle, Skeletalen
dc.titleAnoxia- and hypoxia-induced expression of LDH-A* in the Amazon Oscar, Astronotus crassipinisen
dc.publisher.journalGenetics and Molecular Biologypt_BR
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