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Title: Evidence of two lineages of the dengue vector Aedes aegypti in the Brazilian Amazon, based on mitochondrial DNA ND4 gene sequences
Authors: Lima, Raimundo Sousa
Scarpassa, Vera Margarete
Keywords: Dna, Mitochondrial
Reduced Nicotinamide Adenine Dinucleotide Dehydrogenase
Reduced Nicotinamide Adenine Dinucleotide Dehydrogenase 4
Unclassified Drug
Aedes Aegypti
Controlled Study
Disease Carrier
Gene Frequency
Gene Sequence
Genetic Distance
Genetic Variability
Geographical Variation (species)
Nucleotide Sequence
Aedes Aegypti
Issue Date: 2009
metadata.dc.publisher.journal: Genetics and Molecular Biology
metadata.dc.relation.ispartof: Volume 32, Número 2, Pags. 414-422
Abstract: Genetic variation was estimated in ten samples populations of Aedes aegypti from the Brazilian Amazon, by using a 380 bp fragment of the mitochocondrial NADH dehydrogenase subunit 4 (ND4) gene. A total of 123 individuals were analyzed, whereby 13 haplotypes were found. Mean genetic diversity was slightly high (h = 0.666 ± 0.029; π = 0.0115 ± 0.0010). Two AMOVA analyses indicated that most of the variation (∼70%-72%) occurred within populations. The variation found among and between populations within the groups disclosed lower, but even so, highly significant values. FST values were not significant in most of the comparisons, except for the samples from Pacaraima and Rio Branco. The isolation by distance (IBD) model was not significant (r = 0.2880; p = 0.097) when the samples from Pacaraima and Rio Branco were excluded from the analyses, this indicating that genetic distance is not related to geographic distance. This result may be explained either by passive dispersal patterns (via human migrations and commercial exchange) or be due to the recent expansion of this mosquito in the Brazilian Amazon. Phylogenetic relationship analysis showed two genetically distinct groups (lineages) within the Brazilian Amazon, each sharing haplotypes with populations from West Africa and Asia. Copyright © 2009, Sociedade Brasileira de Genética.
metadata.dc.identifier.doi: 10.1590/S1415-47572009005000036
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