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Title: Reduced levels of genetic variation in Aedes albopictus (Diptera: Culicidae) from Manaus, Amazonas State, Brazil, based on analysis of the mitochondrial DNA ND5 gene
Authors: Maia, R. T.
Scarpassa, Vera Margarete
Maciel-Litaiff, L. H.
Tadei, Wanderli Pedro
Keywords: Dna, Mitochondrial
Reduced Nicotinamide Adenine Dinucleotide Dehydrogenase
Reduced Nicotinamide Adenine Dinucleotide Dehydrogenase Subunit 5
Unclassified Drug
Aedes Albopictus
Controlled Study
Dna Determination
Gene Structures
Genetic Linkage
Genetic Variability
Mutational Analysis
Nucleotide Sequence
Genetics, Population
Population Structure
Structure Analysis
United States
Dna, Mitochondrial
Gene Flow
Genes, Insect
Genes, Mitochondrial
Genetic Variation
Aedes Albopictus
Issue Date: 2009
metadata.dc.publisher.journal: Genetics and Molecular Research
metadata.dc.relation.ispartof: Volume 8, Número 3, Pags. 998-1007
Abstract: Aedes albopictus, a mosquito originally from Southeast Asia, is considered to be one of the main vectors of dengue fever, yellow fever and other arboviruses. We examined the genetic variability and population structure of 68 individuals of Ae. albopictus collected from five neighborhoods of the city of Manaus, based on the mitochondrial gene coding for NADH dehydrogenase subunit 5 (ND5). Two haplotypes were found, separated by a single mutational event (T ↔ C), with extremely low levels of genetic variability (h = 0.187 ± 0.059; π = 0.00044 ± 0.00014). Based on AMOVA, we concluded that most of the variation (99.08%) occurred within populations, though the levels of variation were not significant. Neutrality tests (Tajima's D and Fu's Fs) were non-significant, indicating that these populations are in genetic equilibrium. The most frequent haplotype (H1) is restricted to Brazilian populations of Ae. albopictus, while the rarer haplotype (H2) is shared with populations from the United States and Asia. We suggest that the reduced variability and low genetic structure identified in our study is a consequence of the recent introduction of this species in Manaus, possibly through a founder effect, followed by expansion throughout the city neighborhoods. Genetic similarity would therefore be due to insufficient time to have accumulated genetic differences between the populations of Ae. albopictus and not to extensive gene flow among them. ©FUNPEC-RP.
metadata.dc.identifier.doi: 10.4238/vol8-3gmr624
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