Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/15005
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dc.contributor.authorRafael, Míriam Silva-
dc.contributor.authorHereira-Rojas, W. J.-
dc.contributor.authorRoper, James J.-
dc.contributor.authorNunomura, Sergio Massayoshi-
dc.contributor.authorTadei, Wanderli Pedro-
dc.date.accessioned2020-05-07T14:00:29Z-
dc.date.available2020-05-07T14:00:29Z-
dc.date.issued2008-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/15005-
dc.description.abstractDillapiol, a phenylpropanoid isolate from essential oils of leaves of Piper aduncum (Piperaceae), has insecticidal, fungicidal and antimicrobial activities. The insecticidal activity of dillapiol was tested in vivo on the larvae and pupae of Aedes aegypti, the mosquito vector of dengue. Specifically, the effect of dillapiol on the formation of micronuclei and chromosome aberrations was analyzed. Dillapiol treatments comprised two concentrations of 200 and 400 micro dissolved in well water, and a pure well water control used to rear four generations of mosquitoes. Micronuclei occurred in mitotic diploid and tetraploid chromosomes of larvae; nuclear abnormalities also occurred in interphase, metaphase, telophase, and single nucleus cells of pupae. Mortality, oviposition, chromosome breakage, and anaphase bridges were significantly greater in the extract treatments than in controls. The genotoxic effects of dillapiol described here suggest that this natural product may be a useful alternative for the control of A. aegypti.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 7, Número 3, Pags. 772-781pt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectPlant Extracten
dc.subjectAedesen
dc.subjectAnimalsen
dc.subjectChemistryen
dc.subjectCytologyen
dc.subjectDrug Effecten
dc.subjectFemaleen
dc.subjectGrowth, Development And Agingen
dc.subjectInterphaseen
dc.subjectLarvaen
dc.subjectMosquitoen
dc.subjectPiperaceaeen
dc.subjectAedesen
dc.subjectAnimalen
dc.subjectFemaleen
dc.subjectInterphaseen
dc.subjectLarvaen
dc.subjectMosquito Controlen
dc.subjectPiperen
dc.subjectPlant Extractsen
dc.titlePotential control of Aedes aegypti (Diptera: Culicidae) with Piper aduncum L. (Piperaceae) extracts demonstrated by chromosomal biomarkers and toxic effects on interphase nuclei.en
dc.typeArtigopt_BR
dc.identifier.doi10.4238/vol7-3gmr481-
dc.publisher.journalGenetics and Molecular Researchpt_BR
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