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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Oliveira, Fabiana da Rocha | - |
dc.contributor.author | Noronha, Maria das Dores Nogueira | - |
dc.contributor.author | Lozano, Jorge Luis López | - |
dc.date.accessioned | 2020-05-07T14:08:31Z | - |
dc.date.available | 2020-05-07T14:08:31Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/15170 | - |
dc.description.abstract | Introduction: The coral snake Micrurus surinamensis, which is widely distributed throughout Amazonia, has a neurotoxic venom. It is important to characterize the biological and molecular properties of this venom in order to develop effective antitoxins. Methods: Toxins from the venom of M. surinamensis were analyzed by two-dimensional polyacrylamide gel electrophoresis and their neurotoxic effects in vivo were evaluated. Results and Conclusions: Most proteins in the venom had masses < 14kDa, low phospholipase A2 activity, and no proteolytic activity. The toxins inhibited the coagulation cascade. The venom had neurotoxic effects in mice, with a median lethal dose upon intravenous administration of 700 µg/kg. Immunogenic studies revealed abundant cross-reactivity of antielapidic serum with 14kDa toxins and limited cross-reactivity with toxins < 10kDa. These results indicate that antielapidic serum against M. surinamensis venom has weak potency (0.35mg/ml) in mice. © 2017, Sociedade Brasileira de Medicina Tropical. All rights reserved. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 50, Número 3, Pags. 365-373 | pt_BR |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Brazil | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/br/ | * |
dc.subject | Hyaluronidase | en |
dc.subject | Phospholipase A2 | en |
dc.subject | Snake Venom | en |
dc.subject | Snake Venom Antiserum | en |
dc.subject | Phospholipase A2 | en |
dc.subject | Animals Experiment | en |
dc.subject | Animals Model | en |
dc.subject | Anticoagulation | en |
dc.subject | Biological Activity | en |
dc.subject | Bleeding | en |
dc.subject | Enzyme Activity | en |
dc.subject | Hypersensitivity | en |
dc.subject | Ld 50 | en |
dc.subject | Micrurus Surinamensis | en |
dc.subject | Mouse | en |
dc.subject | Neurotoxicity | en |
dc.subject | Nonhuman | en |
dc.subject | Electrophoresis, Polyacrylamide Gel | en |
dc.subject | Protein Degradation | en |
dc.subject | Snake | en |
dc.subject | Western Blotting | en |
dc.subject | Zymography | en |
dc.subject | Animals | en |
dc.subject | Bagg Albino Mouse | en |
dc.subject | Chemistry | en |
dc.subject | Cross Reaction | en |
dc.subject | Elapidae | en |
dc.subject | Electrophoresis | en |
dc.subject | Enzymology | en |
dc.subject | Genetics | en |
dc.subject | Metabolism | en |
dc.subject | Animal | en |
dc.subject | Cross Reactions | en |
dc.subject | Elapid Venoms | en |
dc.subject | Elapidae | en |
dc.subject | Electrophoresis | en |
dc.subject | Lethal Dose 50 | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred Balb C | en |
dc.subject | Phospholipases A2 | en |
dc.title | Biological and molecular properties of yellow venom of the Amazonian coral snake Micrurus surinamensis | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1590/0037-8682-0408-2016 | - |
dc.publisher.journal | Revista da Sociedade Brasileira de Medicina Tropical | pt_BR |
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