Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/15645
Título: | High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon |
Autor: | Almeida, Anne Cristine Gomes Kuehn, Andrea Castro, Arthur J.M. Vítor-Silva, Sheila Figueiredo, Erick F.G. Brasil, Larissa Wanderley Brito, Marcelo Augusto Mota S. Sampaio, Vanderson Bassat, Quique Felger, Ingrid Tadei, Wanderli Pedro Monteiro, Wuelton Marcelo Mueller, Ivo Lacerda, Marcus V. G. |
Palavras-chave: | Adolescent Adult Aged Amazonas Asymptomatic Disease Child Controlled Study Cross-sectional Study Disease Carrier Gametocyte Household Human Human Cell Major Clinical Study Middle Aged Nonhuman Parasite Identification Parasite Transmission Parasitemia Plasmodium Vivax Plasmodium Vivax Malaria Child, Preschool Prevalence Reverse Transcription Polymerase Chain Reaction School Child Urban Area Young Adult Asymptomatic Infection City Planning Family Size Female Genetics Isolation And Purification Male Microscopy Parasitemia Parasitology Plasmodium Vivax Malaria Questionnaires Real-time Polymerase Chain Reaction Transmission Ultrastructure Protozoal Dna Adolescent Adult Asymptomatic Infections Child Child, Preschool Cross-sectional Studies Disease Reservoirs Dna, Protozoan Family Characteristics Female Humans Malaria, Vivax Male Microscopy Middle Aged Parasitemia Plasmodium Vivax Prevalence Real-time Polymerase Chain Reaction Surveys And Questionnaires Urban Renewal Young Adult |
Data do documento: | 2018 |
Revista: | Parasites and Vectors |
É parte de: | Volume 11, Número 1 |
Abstract: | Background: Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. and gametocyte burden on symptomatic and asymptomatic infections in the Brazilian Amazon. Results: Two cross-sectional household surveys (CS) were conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were detected by LM and RT-qPCR. A total of 4083 participants were enrolled during the two surveys. In CS1, the prevalence of Plasmodium vivax infections was 4.3% (86/2010) by qPCR and 1.6% (32/2010) by LM. Fifty percent (43/86) of P. vivax infected individuals (qPCR) carried P. vivax gametocytes. In CS2, 3.4% (70/2073) of participants had qPCR-detectable P. vivax infections, of which 42.9% (30/70) of infections were gametocyte positive. The P. vivax parasite density was associated with gametocyte carriage (P < 0.001). Sixty-seven percent of P. vivax infected individuals and 53.4% of P. vivax gametocyte carriers were asymptomatic. Conclusions: This study confirms a substantial proportion of asymptomatic and submicroscopic P. vivax infections in the study area. Most asymptomatic individuals carried gametocytes and presented low asexual parasitemia. This reservoir actively contributes to malaria transmission in the Brazilian Amazon, underscoring a need to implement more efficient control and elimination strategies. © 2018 The Author(s). |
DOI: | 10.1186/s13071-018-2787-7 |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
artigo-inpa.pdf | 942,87 kB | Adobe PDF | Visualizar/Abrir |
Este item está licenciada sob uma Licença Creative Commons