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Título: | Ancient horizontal transfers of retrotransposons between birds and ancestors of human pathogenic nematodes |
Autor: | Suh, Alexander Witt, Christopher C. Menger, Juliana Sadanandan, Keren R. Podsiadlowski, Lars Gerth, Michael Weigert, Anne McGuire, Jimmy A. Mudge, Joann Edwards, Scott V. Rheindt, Frank E. |
Palavras-chave: | Genomic Dna Retroposon Biodiversity Bird Evolution Filariasis Gene Flow Genomics Host Range Nematode Paleobiogeography Pathogen Phylogenetics Prehistoric 3' Untranslated Region 5' Untranslated Region Bird Brugia Consensus Sequence Dna Sequence Genome Host Range Nematode Nonhuman Open Reading Frame Phylogeny Polymerase Chain Reaction Restriction Site Retroposon Sister Group Transposon Wuchereria Wuchereria Bancrofti Animals Bird Bird Diseases Classification Elephantiasis, Filarial Evolution Filariasis Genetics History Gene Transfer, Horizontal Human Loa Loiasis Parasitology Phylogeography Retroposon Transmission Aves Brugia Hexapoda Mammalia Nematoda Wuchereria Animal Biological Evolution Bird Diseases Birds Brugia Elephantiasis, Filarial Filariasis Gene Transfer, Horizontal History, Ancient Humans Loa Loiasis Phylogeny Phylogeography Retroelements Wuchereria |
Data do documento: | 2016 |
Revista: | Nature Communications |
É parte de: | Volume 7 |
Abstract: | Parasite host switches may trigger disease emergence, but prehistoric host ranges are often unknowable. Lymphatic filariasis and loiasis are major human diseases caused by the insect-borne filarial nematodes Brugia, Wuchereria and Loa. Here we show that the genomes of these nematodes and seven tropical bird lineages exclusively share a novel retrotransposon, AviRTE, resulting from horizontal transfer (HT). AviRTE subfamilies exhibit 83-99% nucleotide identity between genomes, and their phylogenetic distribution, paleobiogeography and invasion times suggest that HTs involved filarial nematodes. The HTs between bird and nematode genomes took place in two pantropical waves, >25-22 million years ago (Myr ago) involving the Brugia/Wuchereria lineage and >20-17 Myr ago involving the Loa lineage. Contrary to the expectation from the mammal-dominated host range of filarial nematodes, we hypothesize that these major human pathogens may have independently evolved from bird endoparasites that formerly infected the global breadth of avian biodiversity. |
DOI: | 10.1038/ncomms11396 |
Aparece nas coleções: | Artigos |
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