Use este identificador para citar ou linkar para este item: https://repositorio.inpa.gov.br/handle/1/15936
Título: Biological activities of amazonian species of rubiaceae
Título(s) alternativo(s): Atividades biológicas de espécies amazônicas de Rubiaceae
Autor: Mesquita, Denny Willian Oliveira
Mesquita, Adriana Spirotto Stein
Cursino, Lorena Mayara de Carvalho
Souza, E. S.
Oliveira, A C
Pinheiro, Carlos Cleomir S.
Novaes, J. A P
Oliveira, J. A.A.
Nunez, C. V.
Palavras-chave: Duroia Saccifera Extract
Ferdinandusa Goudotiana Extract
Ferdinandusa Hirsuta Extract
Ferdinandusa Paraensis Extract
Palicourea Corymbifera Extract
Palicourea Guianensis Extract
Unclassified Drug
Abts Radical Scavenging Assay
Agar Diffusion
Animals Model
Anti-fungal Activity
Antioxidant Activity
Artemia Salina
Arthroderma Gypseum
Arthroderma Otae
Biological Activity
Candida Albicans
Cladosporium Cladosporioides
Cladosporium Sphaerospermum
Cytotoxicity
Dpph Radical Scavenging Assay
Duroia Saccifera
Epidermophyton Floccosum
Ferdinandusa Goudotiana
Ferdinandusa Hirsuta
Ferdinandusa Paraensis
Fusarium
Nonhuman
Palicourea Corymbifera
Palicourea Guianensis
Plant Leaf
Rubiaceae
Scytalidium
Toxicity Testing
Trichophyton Mentagrophytes
Trichophyton Rubrum
Trichophyton Tonsurans
Data do documento: 2015
Revista: Revista Brasileira de Plantas Medicinais
É parte de: Volume 17, Número 4, Pags. 604-613
Abstract: Rubiaceae is a plant family with great chemical and biological potential. In this work a phytochemical prospection was performed and it was assessed the cytotoxic, antioxidant and antifungal activities of dichloromethanic and methanolic extracts of the leaves of Duroia saccifera, Ferdinandusa goudotiana, F. hirsuta, F. paraensis, Ferdinandusa sp., Palicourea corymbifera and P. guianensis. The cytotoxicity evaluation was carried out using the test toxicity on Artemia salina. The antifungal activity was determined by agar diffusion method using fungi: Epidermophyton floccosum, Microsporum canis 32905, M. gipseum 29/00, Trichophyton mentagrophytes ATCC 9533/03, T. rubrum ATCC 28189, T. tonsurans 21/97, Cladosporium cladosporioides, C. sphaerospermum, Fusarium U. 662/06, Scytalidium U. 661/06, Candida albicans ATCC 3632 and C. albicans U. 5/99. The antioxidant activity was determined by testing the amount of free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the discoloration of the radical cation 6-sulfonic acid-2,2-azinobis-3-ethylbenzothiazoline (ABTS). For the toxicity test on A. salina greater toxicity in the methanol extract of F. goudotiana was observed, which proved to be toxic up to a concentration of 5 μg mL-1. The presence of antifungal principles was observed in the F. hirsuta and F. paraensis against four tested fungi. In the evaluation of the antioxidant activity, the methanol extracts showed greater activity than the dichloromethanic ones, being similar the obtained result through both methods (reduction of DDPH and ABTS decolorization). The results create possibilities for future researches related to the structure and activity of the components of each active extract. © 2015, Instituto de Biociencias. All rights reserved.
DOI: 10.1590/1983-084X/12_153
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