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Campo DC | Valor | Idioma |
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dc.contributor.author | Pereira, Tiago B. | - |
dc.contributor.author | Silva, Luiz Francisco Rocha e | - |
dc.contributor.author | Amorim, Rodrigo C.N. | - |
dc.contributor.author | Melo, Márcia R.S. | - |
dc.contributor.author | Zacardi de Souza, Rita C. | - |
dc.contributor.author | Eberlin, M. N. | - |
dc.contributor.author | Lima, Emerson Silva | - |
dc.contributor.author | Vasconcellos, Marne Carvalho de | - |
dc.contributor.author | Pohlit, Adrian Martin | - |
dc.date.accessioned | 2020-05-21T20:06:20Z | - |
dc.date.available | 2020-05-21T20:06:20Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://repositorio.inpa.gov.br/handle/1/15981 | - |
dc.description.abstract | Background: Carapa guianensis is a cultivable tree used by traditional health practitioners in the Amazon region to treat several diseases and particularly symptoms related to malaria. Abundant residual pressed seed material (RPSM) results as a by-product of carapa or andiroba oil production. The objective of this study was to evaluate the in vitro and in vivo anti-malarial activity and cytotoxicity of limonoids isolated from C. guaianensis RPSM.Methods. 6-acetoxyepoxyazadiradione (1), andirobin (2), 6-acetoxygedunin (3) and 7-deacetoxy-7-oxogedunin (4) (all isolated from RPSM using extraction and chromatography techniques) and 6-hydroxy-deacetylgedunin (5) (prepared from 3) were evaluated using the micro test on the multi-drug-resistant Plasmodium falciparum K1 strain. The efficacy of limonoids 3 and 4 was then evaluated orally and subcutaneously in BALB/c mice infected with chloroquine-sensitive Plasmodium berghei NK65 strain in the 4-day suppressive test.Results: In vitro, limonoids 1-5 exhibited median inhibition concentrations (IC50) of 20.7-5.0 μM, respectively. In general, these limonoids were not toxic to normal cells (MRC-5 human fibroblasts). In vivo, 3 was more active than 4. At oral doses of 50 and 100 mg/kg/day, 3 suppressed parasitaemia versus untreated controls by 40 and 66%, respectively, evidencing a clear dose-response.Conclusion: 6-acetoxygedunin is an abundant natural product present in C. guianensis residual seed materials that exhibits significant in vivo anti-malarial properties. © 2014 Pereira et al.; licensee BioMed Central Ltd.x. | en |
dc.language.iso | en | pt_BR |
dc.relation.ispartof | Volume 13, Número 1 | pt_BR |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Brazil | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/br/ | * |
dc.subject | 6alpha Acetoxyepoxyazadiradione | en |
dc.subject | 6alpha Acetoxygedunin | en |
dc.subject | 6alpha Hydroxydeacetylgedunin | en |
dc.subject | 7 Deacetoxy 7 Oxogedunin | en |
dc.subject | Andirobin | en |
dc.subject | Antimalarial Agent | en |
dc.subject | Limonoid | en |
dc.subject | Plant Extract | en |
dc.subject | Unclassified Drug | en |
dc.subject | Antimalarial Agent | en |
dc.subject | Limonoid | en |
dc.subject | Plant Extract | en |
dc.subject | Animals Experiment | en |
dc.subject | Animals Model | en |
dc.subject | Antimalarial Activity | en |
dc.subject | Carapa Guianensis | en |
dc.subject | Controlled Study | en |
dc.subject | Dose Response | en |
dc.subject | Drug Cytotoxicity | en |
dc.subject | Drug Efficacy | en |
dc.subject | Drug Screening | en |
dc.subject | Fibroblast | en |
dc.subject | Human | en |
dc.subject | Human Cell | en |
dc.subject | Ic 50 | en |
dc.subject | In Vitro Study | en |
dc.subject | In Vivo Study | en |
dc.subject | Medicinal Plant | en |
dc.subject | Meliaceae | en |
dc.subject | Minimum Inhibitory Concentration | en |
dc.subject | Mouse | en |
dc.subject | Nonhuman | en |
dc.subject | Seed Plant | en |
dc.subject | Plasmodium Berghei Infection | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | Animals | en |
dc.subject | Bagg Albino Mouse | en |
dc.subject | Cell Line | en |
dc.subject | Chemistry | en |
dc.subject | Drug Effects | en |
dc.subject | Female | en |
dc.subject | Malaria | en |
dc.subject | Meliaceae | en |
dc.subject | Plasmodium Berghei | en |
dc.subject | Animal | en |
dc.subject | Antimalarials | en |
dc.subject | Cell Line | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Inhibitory Concentration 50 | en |
dc.subject | Limonins | en |
dc.subject | Malaria | en |
dc.subject | Meliaceae | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred Balb C | en |
dc.subject | Plant Extracts | en |
dc.subject | Plasmodium Berghei | en |
dc.subject | Plasmodium Falciparum | en |
dc.subject | Seeds | en |
dc.title | In vitro and in vivo anti-malarial activity of limonoids isolated from the residual seed biomass from Carapa guianensis (andiroba) oil production | en |
dc.type | Artigo | pt_BR |
dc.identifier.doi | 10.1186/1475-2875-13-317 | - |
dc.publisher.journal | Malaria Journal | pt_BR |
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