Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/16000
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dc.contributor.authorOliveira, A. B.-
dc.contributor.authorBarbosa, Gleyce dos Santos-
dc.contributor.authorVerdam, Maria Christina dos Santos-
dc.contributor.authorOhana, Débora Teixeira-
dc.contributor.authorMendonça, Maria Silvia de-
dc.contributor.authorAlves Meira, Renata Maria Strozi-
dc.date.accessioned2020-05-21T21:37:10Z-
dc.date.available2020-05-21T21:37:10Z-
dc.date.issued2014-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/16000-
dc.description.abstractThe Scutellaria agrestis is used by Amazonas riverine communities, especially for otitis externa topical treatment, by using the crude extract obtained by maceration. This study aimed to investigate the preliminary phytochemical profile, the safety/toxicity and the analgesic, anti-inflammatory and antiedematogenic activities of the aqueous extract of the S. agrestis leaves. Eighty individuals were collected at the Nilton Lins University medicinal garden, Manaus, Brazil. The phytochemical profile was obtained through a plant drug survey for cyanogenic heterosides, terpenes, alkaloids and phenolic compounds. The extract safety was evaluated by acute toxicity test. Analgesic and anti-inflammatory activities were accessed using formalin test in mice and the antiedematogenic activity, using paw edema test in mice. We detected phenolic (hydrolysable tannins, coumarins and several classes of flavonoids) and terpenoid (free steroids, saponins) metabolites. We could not establish LD50because no animals died during the acute toxicity test, probably because of the absence of cyanogenic glycosides on the composition of the extract. However, we found that the extract is slightly toxic as animal spasms were observed in the first hour of the test. The extract showed significant analgesic and anti-inflammatory activity on the formalin test (30, 100 and 300 mg/kg p.o.), and the highest dose result was equivalent to the standard drug (Fentanyl). However, no significant antiedematogenic effect was observed during the paw edema test. The results obtained in this study provide preliminary scientific basis about the safety and analgesic/anti-inflammatory actions of the aqueous extract of S. agrestis, which indicates that this species is a promising option for further in vitro and in vivo pharmacological studies.en
dc.language.isopt_BRpt_BR
dc.relation.ispartofVolume 16, Número 2, Pags. 174-181pt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectAlkaloiden
dc.subjectCyanogenic Heterosideen
dc.subjectPhenol Derivativeen
dc.subjectPlant Extracten
dc.subjectPlant Medicinal Producten
dc.subjectScutellaria Agrestis A Extarcten
dc.subjectTerpeneen
dc.subjectUnclassified Drugen
dc.subjectAnalgesic Activityen
dc.subjectAnimals Experimenten
dc.subjectAnimals Modelen
dc.subjectAntiedematogenic Activityen
dc.subjectAntiinflammatory Activityen
dc.subjectBiological Activityen
dc.subjectControlled Studyen
dc.subjectExternal Otitisen
dc.subjectMouseen
dc.subjectNonhumanen
dc.subjectPaw Edemaen
dc.subjectPhytochemistryen
dc.subjectScutellariaen
dc.subjectToxicity Testingen
dc.titleAnalgesic and anti-inflammatory effect of the aqueous extract of "trevo-roxo" (Scutellaria agrestis A. St.-Hil. Ex Benth. - Lamiaceae) leaves in rodentsen
dc.title.alternativeEfeito analgésico e anti-inflamatório do extrato aquoso das folhas de trevo-roxo (Scutellaria agrestis A. St.-Hil. Ex Benth. - Lamiaceae) em roedorespt_BR
dc.typeArtigopt_BR
dc.identifier.doi10.1590/S1516-05722014000200002-
dc.publisher.journalRevista Brasileira de Plantas Medicinaispt_BR
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