Please use this identifier to cite or link to this item: https://repositorio.inpa.gov.br/handle/1/16049
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dc.contributor.authorMarinotti, Osvaldo-
dc.contributor.authorCerqueira, Gustavo C.-
dc.contributor.authorAlmeida, Luiz G.P.-
dc.contributor.authorFerro, Maria Inês Tiraboschi-
dc.contributor.authorLoreto, Elgion Lúcio da Silva-
dc.contributor.authorZaha, Arnaldo-
dc.contributor.authorTeixeira, Santuza Ribeiro-
dc.contributor.authorWespiser, Adam R.-
dc.contributor.authore Silva, A. A.-
dc.contributor.authorSchlindwein, Aline Daiane-
dc.contributor.authorPacheco, Ana Carolina Landim-
dc.contributor.authorSilva, Artur-
dc.contributor.authorGraveley, Brenton R.-
dc.contributor.authorWalenz, Brian P.-
dc.contributor.authorAraújo Lima, Bruna de-
dc.contributor.authorRibeiro, Carlos Alexandre Gomes-
dc.contributor.authorNunes-Silva, Carlos Gustavo-
dc.contributor.authorCarvalho, Carlos Roberto de-
dc.contributor.authorAlmeida Soares, Célia Maria A. de-
dc.contributor.authorMenezes, Cláudia Beatriz Afonso de-
dc.contributor.authorMatiolli, Cleverson Carlos-
dc.contributor.authorCaffrey, Daniel R.-
dc.contributor.authorAraujo, Demetrius Antonio Machado-
dc.contributor.authorOliveira, Diana Magalhães de-
dc.contributor.authorGolenbock, Douglas T.-
dc.contributor.authorGrisard, Edmundo Carlos-
dc.contributor.authorFantinatti-Garboggini, Fabiana-
dc.contributor.authorCarvalho, Fabíola Marques de-
dc.contributor.authorBarcellos, Fernando Gomes-
dc.contributor.authorProsdocimi, Francisco-
dc.contributor.authorMay, Gemma-
dc.contributor.authorAzevedo Júnior, Gilson Martins de-
dc.contributor.authorGuimarães, Giselle Moura-
dc.contributor.authorGoldman, Gustavo Henrique-
dc.contributor.authorPadilha, Itácio Q.M.-
dc.contributor.authorBatista, Jacqueline da Silva-
dc.contributor.authorFerro, Jesus Aparecido-
dc.contributor.authorRibeiro, J. M.C.-
dc.contributor.authorSerrao, Jose Eduardo Lopes Rangel-
dc.contributor.authorDabbas, Karina Maia-
dc.contributor.authorCerdeira, Louise Teixeira-
dc.contributor.authorAgnez-Lima, Lucymara Fassarella-
dc.contributor.authorBrocchi, Marcelo-
dc.contributor.authorCarvalho, Marcos Oliveira de-
dc.contributor.authorTeixeira, Marcus de Melo-
dc.contributor.authorMascena Diniz Maia, Maria de-
dc.contributor.authorGoldman, Maria Helena S.-
dc.contributor.authorSchneider, Maria Paula Cruz-
dc.contributor.authorFelipe, Maria Sueli Soares-
dc.contributor.authorHungría, Mariangela-
dc.contributor.authorNicolás, Marisa Fabiana-
dc.contributor.authorPereira, Maristela-
dc.contributor.authorMontes, Martín Alejandro-
dc.contributor.authorCantão, Maurício Egídio-
dc.contributor.authorVincentz, Michel G.A.-
dc.contributor.authorRafael, Míriam Silva-
dc.contributor.authorSilverman, Neal-
dc.contributor.authorStoco, Patrícia Hermes-
dc.contributor.authorSouza, Rangel Celso-
dc.contributor.authorVicentini, Renato-
dc.contributor.authorGazzinelli, Ricardo Tostes Ostes-
dc.contributor.authorOliveira Neves, Rogério de-
dc.contributor.authorSilva, Rosane A.-
dc.contributor.authorAstolfi-Filho, Spártaco A.T.-
dc.contributor.authorMaciel, Talles Eduardo Ferreira-
dc.contributor.authorÜrményi, Turán Péter-
dc.contributor.authorTadei, Wanderli Pedro-
dc.contributor.authorCamargo, Erney Plessmann-
dc.contributor.authorVasconcelos, Ana Tereza-
dc.date.accessioned2020-05-22T20:04:32Z-
dc.date.available2020-05-22T20:04:32Z-
dc.date.issued2013-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/16049-
dc.description.abstractAnopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vectorhuman and vectorparasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles- darlingi. © 2013 The Author(s).en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 41, Número 15, Pags. 7387-7400pt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectAnophelesen
dc.subjectAnopheles Darlingien
dc.subjectAnopheles Gambiaeen
dc.subjectCircadian Rhythmen
dc.subjectFemaleen
dc.subjectGene Identificationen
dc.subjectGene Sequenceen
dc.subjectGenetic Conservationen
dc.subjectGenetic Markeren
dc.subjectGenome Analysisen
dc.subjectGenome Sizeen
dc.subjectIndel Mutationen
dc.subjectInsect Geneticsen
dc.subjectInsecticide Resistanceen
dc.subjectMaleen
dc.subjectNonhumanen
dc.subjectPriority Journalen
dc.subjectSequence Homologyen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectSyntenyen
dc.subjectTransposonen
dc.subjectXenobiotic Metabolismen
dc.subjectAnimalen
dc.subjectAnophelesen
dc.subjectChromosomes, Insecten
dc.subjectDna Transposable Elementsen
dc.subjectEvolution, Molecularen
dc.subjectFemaleen
dc.subjectGenetic Variationen
dc.subjectGenome, Insecten
dc.subjectHost-parasite Interactionsen
dc.subjectInsect Proteinsen
dc.subjectInsect Vectorsen
dc.subjectInsecticide Resistanceen
dc.subjectInsecticidesen
dc.subjectMalariaen
dc.subjectMaleen
dc.subjectMolecular Sequence Annotationen
dc.subjectPhylogenyen
dc.subjectSyntenyen
dc.subjectTranscriptomeen
dc.titleThe Genome of Anopheles darlingi, the main neotropical malaria vectoren
dc.typeArtigopt_BR
dc.identifier.doi10.1093/nar/gkt484-
dc.publisher.journalNucleic Acids Researchpt_BR
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