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https://repositorio.inpa.gov.br/handle/1/16091
Título: | Triterpenes from minquartia guianensis (olacaceae) and in vitro antimalarial activity |
Autor: | Cursino, Lorena Mayara de Carvalho Nunez, C. V. Paula, Renata Cristina de Nascimento, Maria Fernanda Alves do dos Santos, Pierre Alexandre Lexandre |
Data do documento: | 2012 |
Revista: | Química Nova |
É parte de: | Volume 35, Número 11, Pags. 2165-2168 |
Abstract: | Minquartia guianensis, popularly known as acariquara, was phytochemically investigated. The following triterpenes were isolated from the dichloromethane extract of leaves: lupen-3-one (1), taraxer-3-one (2) and oleanolic acid (3). The dichloromethane extract of branches yielded the triterpene 3β-methoxy-lup-20(29)-ene (4). The chemical structures were characterized by NMR data. Plant extracts, substance 3, squalene (5) and taraxerol (6), (5 and 6 previously isolated), were evaluated by in vitro assay against chloroquine resistant Plasmodium falciparum. The dichloromethane extract of leaves and the three triterpenes assayed have shown partial activity. Thus, these results demonstrated that new potential antimalarial natural products can be found even in partially active extracts. |
DOI: | 10.1590/S0100-40422012001100011 |
Aparece nas coleções: | Artigos |
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