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Title: | Occurrence and experimental infection of toads (Bufo marinus and B. granulosus) with mycobacterium chelonei subsp. abscessus |
Authors: | Mok, Waiyin Carvalho, C. M. |
Keywords: | Animals Experiment Animals Model Epidemiology Experimental Infection Mycobacterium Chelonei Nonhuman Priority Journal Toad |
Issue Date: | 1984 |
metadata.dc.publisher.journal: | Journal of Medical Microbiology |
metadata.dc.relation.ispartof: | Volume 18, Número 3, Pags. 327-333 |
Abstract: | In a survey of 234 Amazonian toads and frogs, six strains of Mycobacterium chelonei subsp. abscessus were isolated from the liver or spleen of four of 66 Bufo marinus (6.1%) and from the kidney or peritoneal fluid of two of 86 B. granulosus (2.3%). There were no histopathological lesions in the viscera of the infected animals. Experimental infection of 29 captive B. marinus and B. granulosus, by the intraperitoneal route, with a pooled inoculum of M. chelonei subsp. abscessus caused five deaths near the end of a 2-month observation period. M. chelonei subsp. abscessus was isolated from the liver, spleen, kidney, gonad, heart and lung of toads killed at various intervals after inoculation, and intracellular acid-fast bacilli were seen in these organs. Histological evidence of invasion of tissues by mycobacteria became apparent from the 45th day after infection. The susceptibility to infection of B. marinus and B. granulosus suggests that these toads may serve as a fortuitous animal host for M. chelonei subsp. abscessus. |
metadata.dc.identifier.doi: | 10.1099/00222615-18-3-327 |
Appears in Collections: | Artigos |
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