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dc.contributor.authorCosta, Guilherme M.J.-
dc.contributor.authorLacerda, Samyra Maria Santos N.Nassif-
dc.contributor.authorFigueiredo, Andre´ Felipe Almeida-
dc.contributor.authorLeal, Marcelo Castro-
dc.contributor.authorRezende-Neto, José V.-
dc.contributor.authorFrança, Luiz Renato de-
dc.date.accessioned2020-06-15T21:36:43Z-
dc.date.available2020-06-15T21:36:43Z-
dc.date.issued2018-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/16845-
dc.description.abstractTemperature is considered a crucial modulator of reproductive activity and testis homeostasis. It is well known that elevated temperatures cause several effects on testicular components, particularly on germ cells, which might lead to the impairment of spermatogenesis and loss of male fertility. The present study aimed to evaluate the effects of different environmental temperatures on several morphofunctional testis parameters, with emphasis on duration of spermatogenesis and spermatogenic efficiency. Thirty sexually mature Swiss mice (Mus musculus) were allocated in three different experimental groups, being kept in vivarium for three weeks at 16 °C, 23 °C (control group) and 32 °C. In order to estimate the duration of spermatogenesis, three animals per each group received intraperitoneal injections of tritiated thymidine and the testes were perfused-fixed and routinely processed for histological, morphometrical and immunoperoxidase analyses. Although the lower temperature (16 °C) did not change most of the evaluated testicular parameters, our findings showed that higher environmental temperature (32 °C) is able to alter important testis parameters, resulting for instance in acceleration of spermatogenesis, alterations in the stages frequencies, increased number of germ and Leydig cells apoptosis and reduced Sertoli cell and spermatogenic efficiencies. As in many conditions infertile men exhibit higher mean scrotal temperature, we believe that experimental studies with mice involving temperature might represent an interesting approach to better understand the mechanisms related to human testis function and sperm production. © 2018 Elsevier Ltden
dc.language.isoenpt_BR
dc.relation.ispartofVolume 77, Pags. 14-23pt_BR
dc.rightsRestrito*
dc.subjectThymidineen
dc.subjectTestosteroneen
dc.subjectAnimals Cellen
dc.subjectAnimals Experimenten
dc.subjectAnimals Tissueen
dc.subjectApoptosisen
dc.subjectCell Counten
dc.subjectControlled Studyen
dc.subjectEnvironmental Temperatureen
dc.subjectGerm Cellen
dc.subjectHigh Temperatureen
dc.subjectHistologyen
dc.subjectImmunoperoxidase Stainingen
dc.subjectIn Vivo Studyen
dc.subjectLeydig Cellen
dc.subjectLow Temperatureen
dc.subjectMaleen
dc.subjectMorphometryen
dc.subjectMouseen
dc.subjectNonhumanen
dc.subjectSertoli Cellen
dc.subjectSexual Maturationen
dc.subjectSpermatogenesisen
dc.subjectAnimalsen
dc.subjectBlooden
dc.subjectBody Temperatureen
dc.subjectCytologyen
dc.subjectHeaten
dc.subjectHeat Toleranceen
dc.subjectInfertility, Maleen
dc.subjectMetabolismen
dc.subjectPhysiologyen
dc.subjectSpermatocyteen
dc.subjectSpermatozoonen
dc.subjectTestisen
dc.subjectUltrastructureen
dc.subjectAnimalen
dc.subjectApoptosisen
dc.subjectBody Temperatureen
dc.subjectHot Temperatureen
dc.subjectInfertility, Maleen
dc.subjectMaleen
dc.subjectMiceen
dc.subjectSertoli Cellsen
dc.subjectSpermatocytesen
dc.subjectSpermatogenesisen
dc.subjectSpermatozoaen
dc.subjectTestisen
dc.subjectTestosteroneen
dc.subjectThermotoleranceen
dc.titleHigher environmental temperatures promote acceleration of spermatogenesis in vivo in mice (Mus musculus)en
dc.typeArtigopt_BR
dc.identifier.doi10.1016/j.jtherbio.2018.07.010-
dc.publisher.journalJournal of Thermal Biologypt_BR
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