Use este identificador para citar ou linkar para este item:
https://repositorio.inpa.gov.br/handle/1/17011
Título: | MicroRNAs in Sertoli cells: implications for spermatogenesis and fertility |
Autor: | Procópio, Marcela Santos Avelar, Gleide Fernandes de Costa, Guilherme M.J. Lacerda, Samyra Maria Santos N.Nassif Resende, Rodrigo Ribeiro França, Luiz Renato de |
Palavras-chave: | Microrna Microrna 1285 Microrna 133b Microrna 202 5p Microrna 23b Microrna 471 Microrna 762 Unclassified Drug Dead Box Protein Dicer1 Protein, Human Microrna Ribonuclease Iii Apoptosis Biosynthesis Cell Maturation Cell Proliferation Gene Control Gene Expression Gene Mutation Gene Targeting Genetic Association Human Male Fertility Nonhuman Phenotype Priority Journal Review Sertoli Cell Sertoli Cell Only Syndrome Spermatogenesis Testis Animals Genetic Marker Genetics Male Infertility, Male Metabolism Pathophysiology Physiology Pig Sertoli Cell Sertoli Cell Only Syndrome Spermatogenesis Animal Cell Proliferation Dead-box Rna Helicases Genetic Markers Humans Infertility, Male Male Micrornas Ribonuclease Iii Sertoli Cell Only Syndrome Sertoli Cells Spermatogenesis Swine Testis |
Data do documento: | 2017 |
Revista: | Cell and Tissue Research |
É parte de: | Volume 370, Número 3, Pags. 335-346 |
Abstract: | In recent decades, infertility has been considered a major widespread public health issue of very high concern. Currently, almost 50% of infertility cases are due to male factors, including semen disorders, obstructions, cryptorchidism, varicocele and testicular failures, which can occur due to malfunctions in both somatic and germ cells. In this context, besides other approaches, different miRNAs have been used as biomarkers for the diagnosis of male infertility, with different pathologic conditions such as Sertoli cell-only syndrome, mixed atrophy, and germ cell arrest. However, most studies related to male fertility do not point out the functions and cell targets of the described miRNAs. Initial investigations using experimental assays in murine and porcine models were performed, providing the first evidence of the influence of miRNAs on Sertoli cell function including, for instance, proliferation, maturation and hormone responses of these cells. The aim of this mini-review is therefore to summarize our present knowledge of this relevant subject and to highlight the importance of future investigations concerning the miRNA influence in the control of Sertoli cells, spermatogenesis and male fertility. © 2017, Springer-Verlag GmbH Germany. |
DOI: | 10.1007/s00441-017-2667-z |
Aparece nas coleções: | Artigos |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.