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dc.contributor.authorLima, Dhêmerson Souza de-
dc.contributor.authorLeal, Vinicius Nunes Cordeiro-
dc.contributor.authorOgusku, Maurício Morishi-
dc.contributor.authorSadahiro, Aya-
dc.contributor.authorPontillo, Alessandra-
dc.contributor.authorAlencar, Bruna C. de-
dc.date.accessioned2020-06-15T21:38:10Z-
dc.date.available2020-06-15T21:38:10Z-
dc.date.issued2017-
dc.identifier.urihttps://repositorio.inpa.gov.br/handle/1/17024-
dc.description.abstractSiglec-1/CD169 is a sialoadhesin expressed by macrophages thought to function in cell-to-cell interactions. In the lung, the expression of Siglec-1 is specific for alveolar macrophages and single nucleotide polymorphisms (SNPs) in SIGLEC1 have been recently associated with asthma severity. Taking in account the role of alveolar macrophages in the control of M. tuberculosis and the poor literature about the contribution of SIGLEC1 genetics in M. tuberculosis susceptibility and development of pulmonary active TB, selected SNPs in SIGLEC1 were analysed in a case/control cohort from a TB endemic area of Brazil Amazon. Our findings evidenced for the first time the novel association between SIGLEC1 rs3859664 SNP and active pulmonary TB. Intriguingly, carriers of the polymorphism produced less IL-1ß than non-carriers, suggesting the possible involvement of Siglec-1 signalling pathway with inflammasome complex. © 2017 Elsevier B.V.en
dc.language.isoenpt_BR
dc.relation.ispartofVolume 55, Pags. 313-317pt_BR
dc.rightsRestrito*
dc.subjectInflammasomeen
dc.subjectInterleukin-1betaen
dc.subjectInterleukin-1betaen
dc.subjectSialoadhesinen
dc.subjectSiglec1 Protein, Humanen
dc.subjectAdulten
dc.subjectCohort Analysisen
dc.subjectControlled Studyen
dc.subjectCytokine Productionen
dc.subjectDisease Associationen
dc.subjectFemaleen
dc.subjectGeneen
dc.subjectGene Frequencyen
dc.subjectGenetic Associationen
dc.subjectGenetic Susceptibilityen
dc.subjectGenotypeen
dc.subjectHeterozygoteen
dc.subjectHumanen
dc.subjectHuman Cellen
dc.subjectLung Tuberculosisen
dc.subjectMajor Clinical Studyen
dc.subjectMaleen
dc.subjectPriority Journalen
dc.subjectSiglec1 Geneen
dc.subjectSignal Transductionen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectAlleleen
dc.subjectCase Control Studyen
dc.subjectGene Linkage Disequilibriumen
dc.subjectGenetic Predispositionen
dc.subjectGeneticsen
dc.subjectLung Tuberculosisen
dc.subjectMetabolismen
dc.subjectMicrobiologyen
dc.subjectMiddle Ageden
dc.subjectMycobacterium Tuberculosisen
dc.subjectYoung Adulten
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectCase-control Studiesen
dc.subjectFemaleen
dc.subjectGenetic Predisposition To Diseaseen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectInterleukin-1betaen
dc.subjectLinkage Disequilibriumen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMycobacterium Tuberculosisen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectSialic Acid Binding Ig-like Lectin 1en
dc.subjectTuberculosis, Pulmonaryen
dc.subjectYoung Adulten
dc.titlePolymorphisms in SIGLEC1 contribute to susceptibility to pulmonary active tuberculosis possibly through the modulation of IL-1ßen
dc.typeArtigopt_BR
dc.identifier.doi10.1016/j.meegid.2017.09.031-
dc.publisher.journalInfection, Genetics and Evolutionpt_BR
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